LOCUS       SIU00476.1               349 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Magnesium
            and cobalt efflux protein CorC protein.
ACCESSION   LT708304-1889
PROTEIN_ID  SIU00476.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1872C"
                     /note="Mb1872c, -, len: 349 aa. Equivalent to Rv1841c,
                     len: 345 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (98.9% identity in 349 aa overlap). Conserved hypothetical
                     membrane protein. Some similarity to O07585|YHDP_BACSU
                     HYPOTHETICAL 49.9 KD PROTEIN from Bacillus subtilis (444
                     aa), FASTA scores: opt: 620, E(): 0, (31.1% identity in
                     350 aa overlap). Also similar to other Mycobacterium
                     tuberculosis proteins e.g. Rv1842c, Rv2366c.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     12 bp in-frame insertion leads to a longer product
                     compared to its homolog in Mycobacterium tuberculosis
                     strain H37Rv (349 aa versus 345 aa). Protein product from
                     Mb1872c detected using SWATH mass spectrometry. Mb1872c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XZI0"
                     /db_xref="InterPro:IPR000644"
                     /db_xref="InterPro:IPR002550"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZI0"
BEGIN
        1 MDVLSAVLLA LLLIGANAFF VGAEFALISA RRDRLEALAE QGKATAVTVI RAGEQLPAML
       61 TGAQLGVTVS SILLGRVGEP AVVKLLQLSF GLSGVPPALL HTLSLAVALA IVVALHVLLG
      121 EMVPKNIALA GPERTAMLLV PPYLVYVRLA RPFIAFYNNC ANAILRLVGV QPKDELDIAV
      181 STAELSEMIA ESLSEGLLDH EEHTRLTRAL RIRTRLVADV AVPLVNIRAV QVSAVGSGPT
      241 IGGVEQALAQ TGYSRFPVVD RGGRFIGYLH IKDVLTLGDN PQTVIDLAVV RPLPRVPQSL
      301 PLADALSRMR RINSHLALVT ADNGSVVGMV ALEDVVEDLV GTMRDGTHR
//