LOCUS SIU00475.1 466 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 pe- pgrs family protein pe_pgrs34 protein. ACCESSION LT708304-1888 PROTEIN_ID SIU00475.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PE_PGRS34" /locus_tag="BQ2027_MB1871C" /note="Mb1871c, PE_PGRS34, len: 466 aa. Similar to Rv1840c, len: 515 aa, from Mycobacterium tuberculosis strain H37Rv, (90.485% identity in 515 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins. Similar to many e.g. Y03A_MYCTU|Q10637 hypothetical glycine-rich 49.6 kd protein (603 aa), FASTA scores: opt: 1693, E(): 0, (53.1% identity in 612 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an in-frame deletion of 147 bp leads to a longer protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). Mb1871c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR000084" /db_xref="UniProtKB/TrEMBL:A0A1R3Y0B4" BEGIN 1 MSFVVAAPEV VVAAASDLAG IGSAIGAANA AAAVPTMGVL AAGADEVSAA VADLFGAHAQ 61 AYQALSAQAA LFHEQFVHAM TAGAGAYAGA EAADAAALDV LNGPFQALFG RPLIGDGANG 121 APGQPGGPGG LLYGNGGNGG NGGIGQPGGA GGDAGLIGNG GNGGIGGPGA TGLAGGAGGL 181 GKAGFAGGAG GTGGTGGLLY GNGGNGGNVP SGAADGGAGG DARLIGNGGD GGSVGAAPTG 241 IGNGGNGGNG GWLYGDGGSG GSTLQGFSDG GTGGNAGMFG DGGNGGFSFF DGNGGDGGTG 301 GTLIGNGGDG GNSVQTDGFL RGHGGDGGNA VGLIGNGGAG GAGSAGTGVF APGGGSGGNG 361 GNGALLVGNG GAGGSGGPTQ IPSVAVPVTG AGGTGGNGGT AGLIGNGGNG GAAGVSGDGT 421 PGTGGNGGYA QLIGDGGDGG PGDSGGPGGS GGTGGTLAGQ NGSPGG //