LOCUS SIU00470.1 628 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Predicted acyl esterases protein. ACCESSION LT708304-1883 PROTEIN_ID SIU00470.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1866C" /note="Mb1866c, -, len: 628 aa. Equivalent to Rv1835c, len: 628 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 628 aa overlap). Conserved hypothetical protein, some similarity to putative acylases e.g. G216374 glutaryl 7-aca acylase precursor (634 aa) FASTA scores, opt: 202, E(): 3.5e-06, (25.1% identity in 669 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2800 and Rv1215c. Protein product from Mb1866c detected using SWATH mass spectrometry. Mb1866c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A5F6" /db_xref="InterPro:IPR000383" /db_xref="InterPro:IPR005674" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013736" /db_xref="InterPro:IPR029058" /db_xref="UniProtKB/Swiss-Prot:P0A5F6" BEGIN 1 MTRRGGSDAA WYSAPDQRSA YPRYRGMRYS SCYVTMRDGV RIAIDLYLPA GLTSAARLPA 61 ILHQTRYYRS LQLRWPLRML LGGKPLQHIA ADKRRRRRFV ASGYAWVDVD VRGSGASFGA 121 RVCEWSSDEI RDGAEIVDWI VRQPWCNGTV AALGNSYDGT SAELLLVNQH PAVRVIAPCF 181 SLFDVYTDIA FPGGIHAAWF TDTWGRYNEA LDRNALHEVV GWWAKLPVTG MQPVQEDRDR 241 SLRDGAIAAH RGNYDVHQIA GSLTFRDDVS ASDPYRGQPD ARLEPIGTPI ESGSINLISP 301 HNYWRDVQAS GAAIYSYSGW FDGGYAHAAI KRFLTVSTPG SHLILGPWNH TGGWRVDPLR 361 GLSRPDFDHD GELLRFIDHH VKGADTGIGS EPPVHYFTMV ENRWKSADTW PPPATTQSYY 421 LSADRQLRPD APDCDSGADE YVVDQTAGTG ERSRWRSQVG IGGHVCYPDR KAQDAKLLTY 481 TSAPLDHPLE VTGHVVVTLF ITSTSSDGTF FVYLEDVDPR GRVAYITEGQ LRAIHRRLSD 541 GPPPYRQVVP YRTFASGDAW PLVPGEIARL TFDLLPTSYL FQPGHRIRIA IAGADASHFA 601 ILPGCAPTVR VYRSRMHASR IDLPVIQP //