LOCUS       SIU00468.1               286 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Possible
            haloalkane dehalogenase protein.
ACCESSION   LT708304-1881
PROTEIN_ID  SIU00468.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1864C"
                     /note="Mb1864c, -, len: 286 aa. Equivalent to Rv1833c,
                     len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 286 aa overlap). Possible haloalkane
                     dehalogenase (EC 3.8.1.5). Similar to several haloalkane
                     dehalogenase e.g. CAB45532.1|AJ243259 from Mycobacterium
                     bovis (300 aa); also similar to LINB_PSEPA|P51698
                     1,3,4,6-tetrachloro-1,4-cyclohexadien from Pseudomonas
                     paucimobilis (295 aa), FASTA scores: opt: 314, E():
                     1.5e-13, (33.1% identity in 281 aa overlap). Protein
                     product from Mb1864c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1864c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P64304"
                     /db_xref="InterPro:IPR000073"
                     /db_xref="InterPro:IPR000639"
                     /db_xref="InterPro:IPR023489"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/Swiss-Prot:P64304"
BEGIN
        1 MSIDFTPDPQ LYPFESRWFD SSRGRIHYVD EGTGPPILLC HGNPTWSFLY RDIIVALRDR
       61 FRCVAPDYLG FGLSERPSGF GYQIDEHARV IGEFVDHLGL DRYLSMGQDW GGPISMAVAV
      121 ERADRVRGVV LGNTWFWPAD TLAMKAFSRV MSSPPVQYAI LRRNFFVERL IPAGTEHRPS
      181 SAVMAHYRAV QPNAAARRGV AEMPKQILAA RPLLARLARE VPATLGTKPT LLIWGMKDVA
      241 FRPKTIIPRL SATFPDHVLV ELPNAKHFIQ EDAPDRIAAA IIERFG
//