LOCUS       SIU00456.1               808 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            preprotein translocase atpase seca2 protein.
ACCESSION   LT708304-1869
PROTEIN_ID  SIU00456.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="secA2"
                     /locus_tag="BQ2027_MB1852"
                     /note="Mb1852, secA2, len: 808 aa. Equivalent to Rv1821,
                     len: 808 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 808 aa overlap). Possible secA2,
                     preprotein translocase, component of secretion apparatus,
                     similar to several preprotein translocases e.g.
                     P28366|SECA_BACSU preprotein translocase secA subunit from
                     Bacillus subtilis (841 aa), FASTA scores: opt: 1424, E():
                     0, (35.9% identity in 786 aa overlap). Equivalent to
                     AL008609|MLCB1788.45 Preprotein translocase SecA 2 from
                     Mycobacterium leprae (778 aa) (87.1% identity in 780 aa
                     overlap). Also similar to Rv3240c|MTCY20B11.15c secA
                     preprotein translocase from Mycobacterium tuberculosis
                     (949 aa). COULD BE PART OF THE PROKARYOTIC PROTEIN
                     TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c,
                     SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND
                     SECY|Rv0732. Protein product from Mb1852 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1852 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P66786"
                     /db_xref="InterPro:IPR000185"
                     /db_xref="InterPro:IPR011115"
                     /db_xref="InterPro:IPR011116"
                     /db_xref="InterPro:IPR011130"
                     /db_xref="InterPro:IPR014018"
                     /db_xref="InterPro:IPR020937"
                     /db_xref="InterPro:IPR026389"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036266"
                     /db_xref="InterPro:IPR036670"
                     /db_xref="UniProtKB/Swiss-Prot:P66786"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNVHGCPRIA ACRCTDTHPR GRPAFAYRWF VPKTTRAQPG RLSSRFWRLL GASTEKNRSR
       61 SLADVTASAE YDKEAADLSD EKLRKAAGLL NLDDLAESAD IPQFLAIARE AAERRTGLRP
      121 FDVQLLGALR MLAGDVIEMA TGEGKTLAGA IAAAGYALAG RHVHVVTIND YLARRDAEWM
      181 GPLLDAMGLT VGWITADSTP DERRTAYDRD VTYASVNEIG FDVLRDQLVT DVNDLVSPNP
      241 DVALIDEADS VLVDEALVPL VLAGTTHRET PRLEIIRLVA ELVGDKDADE YFATDSDNRN
      301 VHLTEHGARK VEKALGGIDL YSEEHVGTTL TEVNVALHAH VLLQRDVHYI VRDDAVHLIN
      361 ASRGRIAQLQ RWPDGLQAAV EAKEGIETTE TGEVLDTITV QALINRYATV CGMTGTALAA
      421 GEQLRQFYQL GVSPIPPNKP NIREDEADRV YITTAAKNDG IVEHITEVHQ RGQPVLVGTR
      481 DVAESEELHE RLVRRGVPAV VLNAKNDAEE ARVIAEAGKY GAVTVSTQMA GRGTDIRLGG
      541 SDEADHDRVA ELGGLHVVGT GRHHTERLDN QLRGRAGRQG DPGSSVFFSS WEDDVVAANL
      601 DHNKLPMATD ENGRIVSPRT GSLLDHAQRV AEGRLLDVHA NTWRYNQLIA QQRAIIVERR
      661 NTLLRTVTAR EELAELAPKR YEELSDKVSE ERLETICRQI MLYHLDRGWA DHLAYLADIR
      721 ESIHLRALGR QNPLDEFHRM AVDAFASLAA DAIEAAQQTF ETANVLDHEP GLDLSKLARP
      781 TSTWTYMVND NPLSDDTLSA LSLPGVFR
//