LOCUS SIU00454.1 639 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable drug-transport transmembrane atp-binding protein abc transporter baca protein. ACCESSION LT708304-1867 PROTEIN_ID SIU00454.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="baca" /locus_tag="BQ2027_MB1850C" /note="Mb1850c, -, len: 639 aa. Equivalent to Rv1819c, len: 639 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 639 aa overlap). Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), equivalent to AL008609|MLCB1788.47 hypothetical ABC transporter from Mycobacterium leprae (638 aa), (74.9% identity in 634 aa overlap). Also similar to other transmembrane ATP-binding proteins e.g. Q57335|Y036_HAEIN hypothetical ABC transporter ATP-binding protein from Haemophilus influenzae (592 aa), FASTA scores: opt: 1235, E(): 2.8e-61, (40.8% identity in 623 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211 ABC transporters family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Protein product from Mb1850c detected using SWATH mass spectrometry. Mb1850c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1K9" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1K9" BEGIN 1 MGPKLFKPSI DWSRAFPDSV YWVGKAWTIS AICVLAILVL LRYLTPWGRQ FWRITRAYFV 61 GPNSVRVWLM LGVLLLSVVL AVRLNVLFSY QGNDMYTALQ KAFEGIASGD GTVKRSGARG 121 FWMSIGVFSV MAVLHVTRVM ADIYLTQRFI IAWRVWLTHH LTQDWLDGRA YYRDLFIDET 181 IDNPDQRIQQ DVDIFTAGAG GTPNAPSNGT ASTLLFGAVQ SIISVISFTA ILWNLSGTLN 241 IFGVSIPRAM FWTVLVYVFV ATVISFIIGR PLIWLSFRNE KLNAAFRYAL VRLRDAAEAV 301 GFYRGERVEG TQLQRRFTPV IDNYRRYVRR SIAFNGWNLS VSQTIVPLPW VIQAPRLFAG 361 QIDFGDVGQT ATSFGNIHDS LSFFRNNYDA FASFRAAIIR LHGLVDANEK GRALPAVLTR 421 PSDDESVELN DIEVRTPAGD RLIDPLDVRL DRGGSLVITG RSGAGKTTLL RSLAELWPYA 481 SGTLHRPGGE NETMFLSQLP YVPLGTLRDV VCYPNSAAAI PDATLRDTLT KVALAPLCDR 541 LDEERDWAKV LSPGEQQRVA FARILLTKPK AVFLDESTSA LDTGLEFALY QLLRSELPDC 601 IVVSVSHRPA LERLHENQLE LLGGGQWRLA PVEAAPAEV //