LOCUS       SIU00454.1               639 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            drug-transport transmembrane atp-binding protein abc transporter
            baca protein.
ACCESSION   LT708304-1867
PROTEIN_ID  SIU00454.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="baca"
                     /locus_tag="BQ2027_MB1850C"
                     /note="Mb1850c, -, len: 639 aa. Equivalent to Rv1819c,
                     len: 639 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 639 aa overlap). Probable
                     drugs-transport transmembrane ATP-binding protein ABC
                     transporter (see citation below), equivalent to
                     AL008609|MLCB1788.47 hypothetical ABC transporter from
                     Mycobacterium leprae (638 aa), (74.9% identity in 634 aa
                     overlap). Also similar to other transmembrane ATP-binding
                     proteins e.g. Q57335|Y036_HAEIN hypothetical ABC
                     transporter ATP-binding protein from Haemophilus
                     influenzae (592 aa), FASTA scores: opt: 1235, E():
                     2.8e-61, (40.8% identity in 623 aa overlap); etc. Contains
                     PS00017 ATP/GTP-binding site motif A (P-loop), and PS00211
                     ABC transporters family signature. BELONGS TO THE
                     ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).
                     Protein product from Mb1850c detected using SWATH mass
                     spectrometry. Mb1850c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1K9"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR036640"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1K9"
BEGIN
        1 MGPKLFKPSI DWSRAFPDSV YWVGKAWTIS AICVLAILVL LRYLTPWGRQ FWRITRAYFV
       61 GPNSVRVWLM LGVLLLSVVL AVRLNVLFSY QGNDMYTALQ KAFEGIASGD GTVKRSGARG
      121 FWMSIGVFSV MAVLHVTRVM ADIYLTQRFI IAWRVWLTHH LTQDWLDGRA YYRDLFIDET
      181 IDNPDQRIQQ DVDIFTAGAG GTPNAPSNGT ASTLLFGAVQ SIISVISFTA ILWNLSGTLN
      241 IFGVSIPRAM FWTVLVYVFV ATVISFIIGR PLIWLSFRNE KLNAAFRYAL VRLRDAAEAV
      301 GFYRGERVEG TQLQRRFTPV IDNYRRYVRR SIAFNGWNLS VSQTIVPLPW VIQAPRLFAG
      361 QIDFGDVGQT ATSFGNIHDS LSFFRNNYDA FASFRAAIIR LHGLVDANEK GRALPAVLTR
      421 PSDDESVELN DIEVRTPAGD RLIDPLDVRL DRGGSLVITG RSGAGKTTLL RSLAELWPYA
      481 SGTLHRPGGE NETMFLSQLP YVPLGTLRDV VCYPNSAAAI PDATLRDTLT KVALAPLCDR
      541 LDEERDWAKV LSPGEQQRVA FARILLTKPK AVFLDESTSA LDTGLEFALY QLLRSELPDC
      601 IVVSVSHRPA LERLHENQLE LLGGGQWRLA PVEAAPAEV
//