LOCUS       SIU00450.1               234 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-1863
PROTEIN_ID  SIU00450.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1846"
                     /note="Mb1846, -, len: 234 aa. Equivalent to Rv1816, len:
                     234 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 234 aa overlap). Possible
                     transcriptional regulatory protein. MEME analysis suggests
                     similarity to putative Mycobacterium tuberculosis
                     transcriptional regulators, Rv0653c, Rv0681. Contains
                     helix-turn-helix motif at aa 38-59 (+4.30 SD). Protein
                     product from Mb1846 detected using SWATH mass
                     spectrometry. Mb1846 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P67439"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR025996"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="UniProtKB/Swiss-Prot:P67439"
BEGIN
        1 MCQTCRVGKR RDAREQIEAK IVELGRRQLL DHGAAGLSLR AIARNLGMVS SAVYRYVSSR
       61 DELLTLLLVD AYSDLADTVD RARDDTVADS WSDDVIAIAR AVRGWAVTNP ARWALLYGSP
      121 VPGYHAPPDR TAGVATRVVG AFFDAIAAGI ATGDIRLTDD VAPQPMSSDF EKIRQEFGFP
      181 GDDRVVTKCF LLWAGVVGAI SLEVFGQYGA DMLTDPGVVF DAQTRLLVAV LAEH
//