LOCUS SIU00450.1 234 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN protein. ACCESSION LT708304-1863 PROTEIN_ID SIU00450.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1846" /note="Mb1846, -, len: 234 aa. Equivalent to Rv1816, len: 234 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 234 aa overlap). Possible transcriptional regulatory protein. MEME analysis suggests similarity to putative Mycobacterium tuberculosis transcriptional regulators, Rv0653c, Rv0681. Contains helix-turn-helix motif at aa 38-59 (+4.30 SD). Protein product from Mb1846 detected using SWATH mass spectrometry. Mb1846 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P67439" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="UniProtKB/Swiss-Prot:P67439" BEGIN 1 MCQTCRVGKR RDAREQIEAK IVELGRRQLL DHGAAGLSLR AIARNLGMVS SAVYRYVSSR 61 DELLTLLLVD AYSDLADTVD RARDDTVADS WSDDVIAIAR AVRGWAVTNP ARWALLYGSP 121 VPGYHAPPDR TAGVATRVVG AFFDAIAAGI ATGDIRLTDD VAPQPMSSDF EKIRQEFGFP 181 GDDRVVTKCF LLWAGVVGAI SLEVFGQYGA DMLTDPGVVF DAQTRLLVAV LAEH //