LOCUS       SIU00430.1               610 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component ecca5. esx-5 type vii secretion system
            protein. protein.
ACCESSION   LT708304-1843
PROTEIN_ID  SIU00430.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ecca5"
                     /locus_tag="BQ2027_MB1826"
                     /note="Mb1826, -, len: 610 aa. Equivalent to Rv1798, len:
                     610 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 610 aa overlap). Conserved
                     hypothetical protein, similar to several mycobacterial
                     proteins e.g. O05460|MTCY15F10.28|Rv3884c|Z94121 from M.
                     tuberculosis (619 aa), FASTA scores: opt: 669, E(): 0,
                     (31.0% identity in 549 aa overlap); and
                     O33089|MLCB628.18c|Y14967 from Mycobacterium leprae (573
                     aa), FASTA scores: opt: 723, E(): 0, (32.4% identity in
                     568 aa overlap). Also very similar to Rv0282. May belong
                     to the CBXX/CFQX family as last ~320 aa domain very
                     similar to several family members. Contains
                     ATP/GTP-binding site motif A (P-loop; PS00017). Protein
                     product from Mb1826 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1826 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P63745"
                     /db_xref="InterPro:IPR000641"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR003959"
                     /db_xref="InterPro:IPR011990"
                     /db_xref="InterPro:IPR023835"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR041627"
                     /db_xref="UniProtKB/Swiss-Prot:P63745"
BEGIN
        1 MTRPQAAAED ARNAMVAGLL ASGISVNGLQ PSHNPQVAAQ MFTTATRLDP KMCDAWLARL
       61 LAGDQSIEVL AGAWAAVRTF GWETRRLGVT DLQFRPEVSD GLFLRLAITS VDSLACAYAA
      121 VLAEAKRYQE AAELLDATDP RHPFDAELVS YVRGVLYFRT KRWPDVLAQF PEATQWRHPE
      181 LKAAGAAMAT TALASLGVFE EAFRRAQEAI EGDRVPGAAN IALYTQGMCL RHVGREEEAV
      241 ELLRRVYSRD AKFTPAREAL DNPNFRLILT DPETIEARTD PWDPDSAPTR AQTEAARHAE
      301 MAAKYLAEGD AELNAMLGME QAKKEIKLIK STTKVNLARA KMGLPVPVTS RHTLLLGPPG
      361 TGKTSVARAF TKQLCGLTVL RKPLVVETSR TKLLGRYMAD AEKNTEEMLE GALGGAVFFD
      421 EMHTLHEKGY SQGDPYGNAI INTLLLYMEN HRDELVVFGA GYAKAMEKML EVNQGLRRRF
      481 STVIEFFSYT PQELIALTQL MGRENEDVIT EEESQVLLPS YTKFYMEQSY SEDGDLIRGI
      541 DLLGNAGFVR NVVEKARDHR SFRLDDEDLD AVLASDLTEF SEDQLRRFKE LTREDLAEGL
      601 RAAVAEKKTK
//