LOCUS SIU00430.1 610 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 esx conserved component ecca5. esx-5 type vii secretion system protein. protein. ACCESSION LT708304-1843 PROTEIN_ID SIU00430.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ecca5" /locus_tag="BQ2027_MB1826" /note="Mb1826, -, len: 610 aa. Equivalent to Rv1798, len: 610 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 610 aa overlap). Conserved hypothetical protein, similar to several mycobacterial proteins e.g. O05460|MTCY15F10.28|Rv3884c|Z94121 from M. tuberculosis (619 aa), FASTA scores: opt: 669, E(): 0, (31.0% identity in 549 aa overlap); and O33089|MLCB628.18c|Y14967 from Mycobacterium leprae (573 aa), FASTA scores: opt: 723, E(): 0, (32.4% identity in 568 aa overlap). Also very similar to Rv0282. May belong to the CBXX/CFQX family as last ~320 aa domain very similar to several family members. Contains ATP/GTP-binding site motif A (P-loop; PS00017). Protein product from Mb1826 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1826 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P63745" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR023835" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR041627" /db_xref="UniProtKB/Swiss-Prot:P63745" BEGIN 1 MTRPQAAAED ARNAMVAGLL ASGISVNGLQ PSHNPQVAAQ MFTTATRLDP KMCDAWLARL 61 LAGDQSIEVL AGAWAAVRTF GWETRRLGVT DLQFRPEVSD GLFLRLAITS VDSLACAYAA 121 VLAEAKRYQE AAELLDATDP RHPFDAELVS YVRGVLYFRT KRWPDVLAQF PEATQWRHPE 181 LKAAGAAMAT TALASLGVFE EAFRRAQEAI EGDRVPGAAN IALYTQGMCL RHVGREEEAV 241 ELLRRVYSRD AKFTPAREAL DNPNFRLILT DPETIEARTD PWDPDSAPTR AQTEAARHAE 301 MAAKYLAEGD AELNAMLGME QAKKEIKLIK STTKVNLARA KMGLPVPVTS RHTLLLGPPG 361 TGKTSVARAF TKQLCGLTVL RKPLVVETSR TKLLGRYMAD AEKNTEEMLE GALGGAVFFD 421 EMHTLHEKGY SQGDPYGNAI INTLLLYMEN HRDELVVFGA GYAKAMEKML EVNQGLRRRF 481 STVIEFFSYT PQELIALTQL MGRENEDVIT EEESQVLLPS YTKFYMEQSY SEDGDLIRGI 541 DLLGNAGFVR NVVEKARDHR SFRLDDEDLD AVLASDLTEF SEDQLRRFKE LTREDLAEGL 601 RAAVAEKKTK //