LOCUS       SIU00428.1               585 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            proline rich membrane-anchored mycosin mycp5 (serine protease)
            (subtilisin-like protease) (subtilase-like) (mycosin-5)
            protein.
ACCESSION   LT708304-1841
PROTEIN_ID  SIU00428.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mycp5"
                     /locus_tag="BQ2027_MB1824"
                     /note="Mb1824, -, len: 585 aa. Equivalent to Rv1796, len:
                     585 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 585 aa overlap). Conserved
                     hypothetical Pro-rich protease. Member of family with four
                     other Mycobacterium tuberculosis hypothetical proteases
                     including Rv3886c|O05458|MTCY15F10.26|Z94121 (550 aa),
                     FASTA scores: opt: 1173, E(): 0, (47.9% identity in 578 aa
                     overlap); Rv0291, Rv3883c, and Rv3449. Genes all linked to
                     those of ESAT-6 family. Has possible N-terminal signal
                     peptide and hydrophobic anchor-like stretch at C-terminus.
                     Contains two serine protease, subtilase family active site
                     motifs: a aspartic acid active site motif (PS00136); and a
                     histidine active site motif (PS00137). Protein product
                     from Mb1824 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1824 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZD8"
                     /db_xref="InterPro:IPR000209"
                     /db_xref="InterPro:IPR015500"
                     /db_xref="InterPro:IPR023827"
                     /db_xref="InterPro:IPR023834"
                     /db_xref="InterPro:IPR036852"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZD8"
BEGIN
        1 MQRFGTGSSR SWCGRAGTAT IAAVLLASGA LTGLPPAYAI SPPTIDPGAL PPDGPPGPLA
       61 PMKQNAYCTE VGVLPGTDFQ LQPKYMEMLN LNEAWQFGRG DGVKVAVIDT GVTPHPRLPR
      121 LIPGGDYVMA GGDGLSDCDA HGTLVASMIA AVPANGAVPL PSVPRRPVTI PTTETPPPPQ
      181 TVTLSPVPPQ TVTVIPAPPP EEGVPPGAPV PGPEPPPAPG PQPPAVDRGG GTVTVPSYSG
      241 GRKIAPIDNP RNPHPSAPSP ALGPPPDAFS GIAPGVEIIS IRQSSQAFGL KDPYTGDEDP
      301 QTAQKIDNVE TMARAIVHAA NMGASVINIS DVMCMSARNV IDQRALGAAV HYAAVDKDAV
      361 IVAAAGDGSK KDCKQNPIFD PLQPDDPRAW NAVTTVVTPS WFHDYVLTVG AVDANGQPLS
      421 KMSIAGPWVS ISAPGTDVVG LSPRDDGLIN AIDGPDNSLL VPAGTSFSAA IVSGVAALVR
      481 AKFPELSAYQ IINRLIHTAR PPARGVDNQV GYGVVDPVAA LTWDVPKGPA EPPKQLSAPL
      541 VVPQPPAPRD MVPIWVAAGG LAGALLIGGA VFGTATLMRR SRKQQ
//