LOCUS SIU00427.1 503 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 esx conserved component eccd5. esx-5 type vii secretion system protein. probable membrane protein. protein. ACCESSION LT708304-1840 PROTEIN_ID SIU00427.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="eccd5" /locus_tag="BQ2027_MB1823" /note="Mb1823, -, len: 503 aa. Equivalent to Rv1795, len: 503 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 503 aa overlap). Conserved hypothetical membrane protein, has a hydrophilic stretch from ~1-130 then very hydrophobic. Similar to several other mycobacterial proteins, all linked to ESAT-6 family e.g. Rv3887c|MTY15F10.24|Z94121 (509 aa), FASTA scores: opt: 360, E(): 1.6e-15, (26.7% identity in 514 aa overlap); Rv3448, and Rv0290. Protein product from Mb1823 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1823 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XZC1" /db_xref="InterPro:IPR006707" /db_xref="InterPro:IPR024962" /db_xref="UniProtKB/TrEMBL:A0A1R3XZC1" BEGIN 1 MTAVADAPQA DIEGVASPQA VVVGVMAGEG VQIGVLLDAN APVSVMTDPL LKVVNSRLRE 61 LGEAPLEATG RGRWALCLVD GAPLRATQSL TEQDVYDGDR LWIRFIADTE RRSQVIEHIS 121 TAVASDLSKR FARIDPIVAV QVGASMVATG VVLATGVLGW WRWHHNTWLT TIYTAVIGVL 181 VLAVAMLLLM RAKTDADRRV ADIMLMSAIM PVTVAAAAAP PGPVGSPQAV LGFGVLTVAA 241 ALALRFTGRR LGIYTAIVII DALTMLAALA RMVAATSAVT LLSSLLLICV VAYHAAPALS 301 RRLAGIRLPV FPSATSRWVF EARPDLPTTV VVSGGSAPVL EGPSSVRDVL LQAERARSFL 361 SGLLTGLGVM VVVCMTSLCD PHTGQRWLPL ILAGFTSGFL LLRGRSYVDR WQSITLAGTA 421 VIIAAAVCVR YALELSSPLA VSIVAAILVL LPAAGMAAAA HVPHTIYSPL FRKFVEWIEY 481 LCLMPIFPLA LWLMNVYAAI RYR //