LOCUS       SIU00427.1               503 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component eccd5. esx-5 type vii secretion system
            protein. probable membrane protein. protein.
ACCESSION   LT708304-1840
PROTEIN_ID  SIU00427.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="eccd5"
                     /locus_tag="BQ2027_MB1823"
                     /note="Mb1823, -, len: 503 aa. Equivalent to Rv1795, len:
                     503 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 503 aa overlap). Conserved hypothetical
                     membrane protein, has a hydrophilic stretch from ~1-130
                     then very hydrophobic. Similar to several other
                     mycobacterial proteins, all linked to ESAT-6 family e.g.
                     Rv3887c|MTY15F10.24|Z94121 (509 aa), FASTA scores: opt:
                     360, E(): 1.6e-15, (26.7% identity in 514 aa overlap);
                     Rv3448, and Rv0290. Protein product from Mb1823 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1823 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZC1"
                     /db_xref="InterPro:IPR006707"
                     /db_xref="InterPro:IPR024962"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZC1"
BEGIN
        1 MTAVADAPQA DIEGVASPQA VVVGVMAGEG VQIGVLLDAN APVSVMTDPL LKVVNSRLRE
       61 LGEAPLEATG RGRWALCLVD GAPLRATQSL TEQDVYDGDR LWIRFIADTE RRSQVIEHIS
      121 TAVASDLSKR FARIDPIVAV QVGASMVATG VVLATGVLGW WRWHHNTWLT TIYTAVIGVL
      181 VLAVAMLLLM RAKTDADRRV ADIMLMSAIM PVTVAAAAAP PGPVGSPQAV LGFGVLTVAA
      241 ALALRFTGRR LGIYTAIVII DALTMLAALA RMVAATSAVT LLSSLLLICV VAYHAAPALS
      301 RRLAGIRLPV FPSATSRWVF EARPDLPTTV VVSGGSAPVL EGPSSVRDVL LQAERARSFL
      361 SGLLTGLGVM VVVCMTSLCD PHTGQRWLPL ILAGFTSGFL LLRGRSYVDR WQSITLAGTA
      421 VIIAAAVCVR YALELSSPLA VSIVAAILVL LPAAGMAAAA HVPHTIYSPL FRKFVEWIEY
      481 LCLMPIFPLA LWLMNVYAAI RYR
//