LOCUS       SIU00415.1               506 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component eccb5. esx-5 type vii secretion system
            protein. probable membrane protein. protein.
ACCESSION   LT708304-1828
PROTEIN_ID  SIU00415.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="eccb5"
                     /locus_tag="BQ2027_MB1811"
                     /note="Mb1811, -, len: 506 aa. Equivalent to Rv1782, len:
                     506 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 506 aa overlap). Probable conserved
                     membrane protein, similar to four other Mycobacterium
                     tuberculosis hypothetical membrane proteins e.g.
                     O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa), FASTA scores:
                     opt: 1106, E(): 0, (41.2% identity in 485 aa overlap);
                     Rv0283, Rv3450c, and Rv3869, all located near ESAT-6
                     family genes. Also similar to O33088|MLCB628.17C|Y14967
                     cosmid B628 from Mycobacterium leprae (481 aa), (32.7%
                     identity in 486 aa overlap); and equivalent to
                     Q9Z5I3|MLCB596.27|AL035472 hypothetical protein from
                     Mycobacterium leprae (506 aa) (82.6% identity in 506 aa
                     overlap). Has hydrophobic stretch from aa 54-76. Protein
                     product from Mb1811 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1811 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZC8"
                     /db_xref="InterPro:IPR007795"
                     /db_xref="InterPro:IPR042485"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZC8"
BEGIN
        1 MAEESRGQRG SGYGLGLSTR TQVTGYQFLA RRTAMALTRW HVRMEIEPGR RQTLAVVASV
       61 SAALVICLGA LLWSFISPSG QLNESPIIAD RDSGALYVRV GDRLYPALNL ASARLITGRP
      121 DNPHLVRSSQ IATMPRGPLV GIPGAPSSFS PKSPPASSWL VCDTVATSSS IGSLQGVTVT
      181 VIDGTPDLTG HRQILSGSDA VVLRYGGDAW VIREGRRSRI EPTNRAVLLP LGLTPEQVSQ
      241 ARPMSRALFD ALPVGPELLV PEVPNAGGPA TFPGAPGPIG TVIVTPQISG PQQYSLVLGD
      301 GVQTLPPLVA QILQNAGSAG NTKPLTVEPS TLAKMPVVNR LDLSAYPDNP LEVVDIREHP
      361 STCWWWERTA GENRARVRVV SGPTIPVAAT EMNKVVSLVK ADTSGRQADQ VYFGPDHANF
      421 VAVTGNNPGA QTSESLWWVT DAGARFGVED SKEARDALGL TLTPSLAPWV ALRLLPQGPT
      481 LSRADALVEH DTLPMDMTPA ELVVPK
//