LOCUS SIU00415.1 506 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 esx conserved component eccb5. esx-5 type vii secretion system protein. probable membrane protein. protein. ACCESSION LT708304-1828 PROTEIN_ID SIU00415.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="eccb5" /locus_tag="BQ2027_MB1811" /note="Mb1811, -, len: 506 aa. Equivalent to Rv1782, len: 506 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 506 aa overlap). Probable conserved membrane protein, similar to four other Mycobacterium tuberculosis hypothetical membrane proteins e.g. O05449|Rv3895c|MTCY15F10.17|Z94121 (495 aa), FASTA scores: opt: 1106, E(): 0, (41.2% identity in 485 aa overlap); Rv0283, Rv3450c, and Rv3869, all located near ESAT-6 family genes. Also similar to O33088|MLCB628.17C|Y14967 cosmid B628 from Mycobacterium leprae (481 aa), (32.7% identity in 486 aa overlap); and equivalent to Q9Z5I3|MLCB596.27|AL035472 hypothetical protein from Mycobacterium leprae (506 aa) (82.6% identity in 506 aa overlap). Has hydrophobic stretch from aa 54-76. Protein product from Mb1811 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1811 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XZC8" /db_xref="InterPro:IPR007795" /db_xref="InterPro:IPR042485" /db_xref="UniProtKB/TrEMBL:A0A1R3XZC8" BEGIN 1 MAEESRGQRG SGYGLGLSTR TQVTGYQFLA RRTAMALTRW HVRMEIEPGR RQTLAVVASV 61 SAALVICLGA LLWSFISPSG QLNESPIIAD RDSGALYVRV GDRLYPALNL ASARLITGRP 121 DNPHLVRSSQ IATMPRGPLV GIPGAPSSFS PKSPPASSWL VCDTVATSSS IGSLQGVTVT 181 VIDGTPDLTG HRQILSGSDA VVLRYGGDAW VIREGRRSRI EPTNRAVLLP LGLTPEQVSQ 241 ARPMSRALFD ALPVGPELLV PEVPNAGGPA TFPGAPGPIG TVIVTPQISG PQQYSLVLGD 301 GVQTLPPLVA QILQNAGSAG NTKPLTVEPS TLAKMPVVNR LDLSAYPDNP LEVVDIREHP 361 STCWWWERTA GENRARVRVV SGPTIPVAAT EMNKVVSLVK ADTSGRQADQ VYFGPDHANF 421 VAVTGNNPGA QTSESLWWVT DAGARFGVED SKEARDALGL TLTPSLAPWV ALRLLPQGPT 481 LSRADALVEH DTLPMDMTPA ELVVPK //