LOCUS       SIU00410.1               434 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            cytochrome p450 144 CYP144 protein.
ACCESSION   LT708304-1823
PROTEIN_ID  SIU00410.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp144"
                     /locus_tag="BQ2027_MB1806"
                     /note="Mb1806, cyp144, len: 434 aa. Equivalent to Rv1777,
                     len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 434 aa overlap). Probable cyp144,
                     cytochrome p450 (EC 1.14.-.-), similar to
                     CPXM_BACME|Q06069 cytochrome p450 (meg) (EC 1.14.99.-)
                     (410 aa), FASTA scores: opt: 435 E(): 2.3e-16, (28.8%
                     identity in 372 aa overlap). Also similar to several other
                     Mycobacterium tuberculosis p450 genes including Rv0766c,
                     Rv2266, etc. Contains PS00086 Cytochrome P450 cysteine
                     heme-iron ligand signature. BELONGS TO THE CYTOCHROME P450
                     FAMILY."
                     /db_xref="GOA:A0A1R3XZA3"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZA3"
BEGIN
        1 MRRSPKGSPG AVLDLQRRVD QAVSADHAEL MTIAKDANTF FGAESVQDPY PLYERMRAAG
       61 SVHRIANSDF YAVCGWDAVN EAIGRPEDFS SNLTATMTYT AEGTAKPFEM DPLGGPTHVL
      121 ATADDPAHAV HRKLVLRHLA AKRIRVMEQF TVQAADRLWV DGMQDGCIEW MGAMANRLPM
      181 MVVAELIGLP DPDIAQLVKW GYAATQLLEG LVENDQLVAA GVALMELSGY IFEQFDRAAA
      241 DPRDNLLGEL ATACASGELD TLTAQVMMVT LFAAGGESTA ALLGSAVWIL ATRPDIQQQV
      301 RANPELLGAF IEETLRYEPP FRGQYRHVRN ATTLDGTELP ADSHLLLLWG AANRDPAQFE
      361 APGEFRLDRA GGKGHISFGK GAHFCVGAAL ARLEARIVLR LLLDRTSVIE AADVGGWLPS
      421 ILVRRIERLE LAVQ
//