LOCUS SIU00404.1 428 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 l-gulono- 1,4-lactone dehydrogenase protein. ACCESSION LT708304-1817 PROTEIN_ID SIU00404.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1800" /note="Mb1800, -, len: 428 aa. Equivalent to Rv1771, len: 428 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 428 aa overlap). Probable oxidoreductase (EC 1.-.-.-), similar to e.g. GGLO_RAT|P10867 l-gulonolactone oxidase (ec 1.1.3.8) (439 aa), FASTA scores: opt: 862, E(): 0, (34.1% identity in 434 aa overlap). Also shows slight similarity to Mycobacterium tuberculosis oxidoreductase Rv1726|MTCY04C12.11 (22.9% identity in 441 aa overlap) and others e.g. Rv3107c, Rv1257c, Rv2251, etc. Contains PS00862 Oxygen oxidoreductases covalent FAD-binding site. Protein product from Mb1800 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1800 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y038" /db_xref="InterPro:IPR006093" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR007173" /db_xref="InterPro:IPR010031" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="UniProtKB/TrEMBL:A0A1R3Y038" BEGIN 1 MSPIWSNWPG EQVCAPSAIV RPTSEAELAD VIAQAAKRGE RVRAVGSGHS FTDIACTDGV 61 MIDMTGLQRV LDVDQPTGLV TVEGGAKLRA LGPQLAQRRL GLENQGDVDP QSITGATATA 121 THGTGVRFQN LSARIVSLRL VTAGGEVLSL SEGDDYLAAR VSLGALGVIS QVTLQTVPLF 181 TLHRHDQRRS LAQTLERLDE FVDGNDHFEF FVFPYADKAL TRTMHRSDEQ PKPTPGWQRM 241 VGENFENGGL SLICQTGRRF PSVAPRLNRL MTNMMSSSTV QDRAYKVFAT QRKVRFTEME 301 YAIPRENGRE ALQRVIDLVR RRSLPIMFPI EVRFSAPDDS FLSTAYGRDT CYIAVHQYAG 361 MEFESYFRAV EEIMDDYAGR PHWGKRHYQT AATLRERYPQ WDRFAAVRDR LDPDRVFLND 421 YTRRVLGP //