LOCUS       SIU00404.1               428 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 l-gulono-
            1,4-lactone dehydrogenase protein.
ACCESSION   LT708304-1817
PROTEIN_ID  SIU00404.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1800"
                     /note="Mb1800, -, len: 428 aa. Equivalent to Rv1771, len:
                     428 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 428 aa overlap). Probable
                     oxidoreductase (EC 1.-.-.-), similar to e.g.
                     GGLO_RAT|P10867 l-gulonolactone oxidase (ec 1.1.3.8) (439
                     aa), FASTA scores: opt: 862, E(): 0, (34.1% identity in
                     434 aa overlap). Also shows slight similarity to
                     Mycobacterium tuberculosis oxidoreductase
                     Rv1726|MTCY04C12.11 (22.9% identity in 441 aa overlap) and
                     others e.g. Rv3107c, Rv1257c, Rv2251, etc. Contains
                     PS00862 Oxygen oxidoreductases covalent FAD-binding site.
                     Protein product from Mb1800 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1800 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y038"
                     /db_xref="InterPro:IPR006093"
                     /db_xref="InterPro:IPR006094"
                     /db_xref="InterPro:IPR007173"
                     /db_xref="InterPro:IPR010031"
                     /db_xref="InterPro:IPR016166"
                     /db_xref="InterPro:IPR016167"
                     /db_xref="InterPro:IPR016169"
                     /db_xref="InterPro:IPR016171"
                     /db_xref="InterPro:IPR036318"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y038"
BEGIN
        1 MSPIWSNWPG EQVCAPSAIV RPTSEAELAD VIAQAAKRGE RVRAVGSGHS FTDIACTDGV
       61 MIDMTGLQRV LDVDQPTGLV TVEGGAKLRA LGPQLAQRRL GLENQGDVDP QSITGATATA
      121 THGTGVRFQN LSARIVSLRL VTAGGEVLSL SEGDDYLAAR VSLGALGVIS QVTLQTVPLF
      181 TLHRHDQRRS LAQTLERLDE FVDGNDHFEF FVFPYADKAL TRTMHRSDEQ PKPTPGWQRM
      241 VGENFENGGL SLICQTGRRF PSVAPRLNRL MTNMMSSSTV QDRAYKVFAT QRKVRFTEME
      301 YAIPRENGRE ALQRVIDLVR RRSLPIMFPI EVRFSAPDDS FLSTAYGRDT CYIAVHQYAG
      361 MEFESYFRAV EEIMDDYAGR PHWGKRHYQT AATLRERYPQ WDRFAAVRDR LDPDRVFLND
      421 YTRRVLGP
//