LOCUS       SIU00387.1               514 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHOSPHOLIPASE C 4 PLCD protein.
ACCESSION   LT708304-1800
PROTEIN_ID  SIU00387.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="plcD"
                     /locus_tag="BQ2027_MB1784C"
                     /note="Mb1784c, plcD, len: 514 aa. Equivalent to MT1799,
                     len: 514 aa, from Mycobacterium tuberculosis strain
                     CDC1551, (100% identity in 514 aa overlap). Probable plcD,
                     phospholipase C 4 (EC 3.1.4.3) (see citation below),
                     highly similar to other phospholipases e.g.
                     Q04001|PHLA_MYCTU|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c
                     PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA from
                     Mycobacterium tuberculosis (512 aa), FASTA score: opt:
                     2657, E(): 4.9e-156, (71.1% identity in 512 aa overlap);
                     P95246|PHLB_MYCTU|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c
                     PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB from
                     Mycobacterium tuberculosis (512 aa), FASTA score: opt:
                     2638, E(): 7.3e-155, (70.9% identity in 512 aa overlap);
                     etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY.
                     REMARK-M.bovis-M.tuberculosis: No equivalent in
                     Mycobacterium tuberculosis strain H37Rv. Belong to RvD2
                     region."
                     /db_xref="GOA:P0A5R9"
                     /db_xref="InterPro:IPR006311"
                     /db_xref="InterPro:IPR007312"
                     /db_xref="InterPro:IPR017850"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5R9"
BEGIN
        1 MSQSHIGGVS RREFLAKVAA GGAGALMSFA GPVIEKAYGA GPCSGHLTDI EHFVFFMQEN
       61 RSFDHYFGTL SGTDGFNTVS PLFQQKGWNP MTQALDATGV TMPYRFDTTR GPFLDGACVN
      121 DPDHSWVAMH ESWNGGVNDN WLPAQAKTRS AAHTPTVMGY YTRQDIPIHY LLADAFTVCD
      181 RYFCSVLGPT LPNRLYWLSA TIDPDGQNGG PELQSPTFQP VRRFGWRIMP QNLSDAGVSW
      241 KVYRNKTLGP ISSVLTYGSL VTSFKQSADP RSDLVRFGVA PSYPASFAAD VLANRLPRVS
      301 WVIPNVLESE HPAVPAAAGA FAIVNILRIL LANPAVWEKT ALIVSYDENG GFFDHVVPAT
      361 APAGTPGEYV TVPDIDQVPG SGGIRGPIGL GFRVPCFVIS PYSRGPQMVH DTFDHTSQLR
      421 LLETRFGVPV PNLTAWRRSV TGDMTSTFNF AVPPNSSWPN LDYPGLHALS TVPQCVPNAA
      481 LGTINRGIPY RVPDPQIMPT QETTPTRGIP SGPC
//