LOCUS SIU00387.1 514 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE PHOSPHOLIPASE C 4 PLCD protein. ACCESSION LT708304-1800 PROTEIN_ID SIU00387.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="plcD" /locus_tag="BQ2027_MB1784C" /note="Mb1784c, plcD, len: 514 aa. Equivalent to MT1799, len: 514 aa, from Mycobacterium tuberculosis strain CDC1551, (100% identity in 514 aa overlap). Probable plcD, phospholipase C 4 (EC 3.1.4.3) (see citation below), highly similar to other phospholipases e.g. Q04001|PHLA_MYCTU|Rv2351c|PLCA|MTP40|MT2416|MTCY98.20c PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 1 PLCA from Mycobacterium tuberculosis (512 aa), FASTA score: opt: 2657, E(): 4.9e-156, (71.1% identity in 512 aa overlap); P95246|PHLB_MYCTU|PLCB|MPCB|Rv2350c|MT2415|MTCY98.19c PROBABLE MEMBRANE-ASSOCIATED PHOSPHOLIPASE C 2 PLCB from Mycobacterium tuberculosis (512 aa), FASTA score: opt: 2638, E(): 7.3e-155, (70.9% identity in 512 aa overlap); etc. BELONGS TO THE BACTERIAL PHOSPHOLIPASE C FAMILY. REMARK-M.bovis-M.tuberculosis: No equivalent in Mycobacterium tuberculosis strain H37Rv. Belong to RvD2 region." /db_xref="GOA:P0A5R9" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR007312" /db_xref="InterPro:IPR017850" /db_xref="UniProtKB/Swiss-Prot:P0A5R9" BEGIN 1 MSQSHIGGVS RREFLAKVAA GGAGALMSFA GPVIEKAYGA GPCSGHLTDI EHFVFFMQEN 61 RSFDHYFGTL SGTDGFNTVS PLFQQKGWNP MTQALDATGV TMPYRFDTTR GPFLDGACVN 121 DPDHSWVAMH ESWNGGVNDN WLPAQAKTRS AAHTPTVMGY YTRQDIPIHY LLADAFTVCD 181 RYFCSVLGPT LPNRLYWLSA TIDPDGQNGG PELQSPTFQP VRRFGWRIMP QNLSDAGVSW 241 KVYRNKTLGP ISSVLTYGSL VTSFKQSADP RSDLVRFGVA PSYPASFAAD VLANRLPRVS 301 WVIPNVLESE HPAVPAAAGA FAIVNILRIL LANPAVWEKT ALIVSYDENG GFFDHVVPAT 361 APAGTPGEYV TVPDIDQVPG SGGIRGPIGL GFRVPCFVIS PYSRGPQMVH DTFDHTSQLR 421 LLETRFGVPV PNLTAWRRSV TGDMTSTFNF AVPPNSSWPN LDYPGLHALS TVPQCVPNAA 481 LGTINRGIPY RVPDPQIMPT QETTPTRGIP SGPC //