LOCUS       SIU00382.1               532 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            FATTY-ACID-COA LIGASE FADD1 (FATTY-ACID-COA SYNTHETASE)
            (FATTY-ACID-COA SYNTHASE) protein.
ACCESSION   LT708304-1795
PROTEIN_ID  SIU00382.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadD1"
                     /locus_tag="BQ2027_MB1779C"
                     /note="Mb1779c, fadD1, len: 532 aa. Equivalent to Rv1750c,
                     len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 532 aa overlap). Possible fadD1,
                     fatty-acid-CoA synthetase (EC 6.2.1.-), similar in part to
                     others e.g. O35488|VLCS_MOUSE VERY-LONG-CHAIN ACYL-COA
                     SYNTHETASE from Mus musculus (620 aa);
                     NP_113924.1|NM_031736 solute carrier family 27 (fatty acid
                     transporter) member 2 from Rattus norvegicus (620 aa);
                     NP_459076.1|NC_003197 crotonobetaine/carnitine-CoA ligase
                     from Salmonella typhimurium (517 aa); CAIC_ECOLI|P31552
                     probable crotonobetaine/carnitine-coa ligase from
                     Escherichia coli (522 aa), FASTA scores: opt: 448, E():
                     1.9e-21, (25.1% identity in 502 aa overlap); etc. Also
                     highly similar to fadD17|Rv3506|MTV023.13 PROBABLE
                     FATTY-ACID-COA LIGASE from Mycobacterium tuberculosis (502
                     aa); and similar to others from Mycobacterium tuberculosis
                     e.g. fadD6|MTCI364.18|Rv1206|O05307 PROBABLE
                     FATTY-ACID-COA LIGASE (597 aa), FASTA score: (28.3%
                     identity in 519 aa overlap); etc. Contains PS00455
                     Putative AMP-binding domain signature. BELONGS TO THE
                     ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Protein product
                     from Mb1779c detected using SWATH mass spectrometry.
                     Mb1779c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZ72"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="InterPro:IPR030310"
                     /db_xref="InterPro:IPR042099"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ72"
BEGIN
        1 MTDTIQSLLR QHVSDPTIAV KYGGLQWTWS QYLAESAARA AALITIADPQ RPTHIGSLLG
       61 NTPEMLAQLA AAGLGGYVLC GLNTTRRGDA LAADVRRADC QIVVTDADHR ALLDGLDLAG
      121 ARILDTSTPR WAELVAGDGA FVPYREVDTM DPFMMIFTSG TSGNPKAVPV SHLMATFAGR
      181 SLTERFGLTE QDTCYVSMPL FHSNAVVAGW APAVVSGAAI APATFSATGF LDDVRRYHAT
      241 YMNYVGKPLA YILATPERDD DADNPLRVAF GNEANDKDIE EFSRRFGVQV EDGFGSTENA
      301 VIVIREPGTP PGSIGRGAHG VAVYNGETVT ECAVARFDAH GALTNADEAI GELVNTTGSG
      361 FFTGYYNDPE ANAERMRHGM YWSGDLAYRD SEGWIYLAGR TADWMRVDGE NLTAAPIERI
      421 LLRYKAINRV AVYAVPDEYV GDQVMAALVL RAGDTFDPDA FEAFLDAQPD LSTKARPRYI
      481 RIAADLPSTA THKVLKRQLI DEGTAVGKAD TLWVREPRGS AYHHASGPAK AI
//