LOCUS       SIU00375.1               566 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE E PKNE (
            PROTEIN KINASE E) (STPK E) protein.
ACCESSION   LT708304-1788
PROTEIN_ID  SIU00375.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pknE"
                     /locus_tag="BQ2027_MB1772"
                     /note="Mb1772, pknE, len: 566 aa. Equivalent to Rv1743,
                     len: 566 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 566 aa overlap). Probable pknE,
                     transmembrane serine/threonine protein kinase (EC 2.7.1.-)
                     (see citation below), similar to PKN1_MYXXA|P33973
                     serine/threonine-protein kinase pkn1 (693 aa), fasta
                     scores: opt: 542, E(): 1.1e-19, (35.8% identity in 302 aa
                     overlap). Also highly similar to K08G_MYCTU|Q11053
                     probable serine/threonine-protein kinase (626 aa) (59.8%
                     identity in 381 aa overlap). Contains PS00107 Protein
                     kinases ATP-binding region signature. Contains Hank's
                     kinase subdomain. BELONGS TO THE SER/THR FAMILY OF PROTEIN
                     KINASES. Protein product from Mb1772 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1772 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:Q7TZN3"
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR012336"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="InterPro:IPR036249"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TZN3"
BEGIN
        1 MDGTAESREG TQFGPYRLRR LVGRGGMGDV YEAEDTVRER IVALKLMSET LSSDPDFRTR
       61 MQREARTAGR LQEPHVVPIH DFGEIDGQLY VDMRLINGVD LAAMLRRQGP LAPPRAVAIV
      121 RQIGSALDAA HAAGATHRDV KPENILVSAD DFAYLVDFGI ASATTDEKLT QLGNTVGTLY
      181 YMAPERFSES HATYRADIYA LTCVLYECLT GSPPYQGDQL SVMGAHINQA IPRPSTVRPG
      241 IPVAFDAVIA RGMAKNPEDR YVTCGDLSAA AHAALATADQ DRATDILRRS QVAKLPVPST
      301 HPVSPGTRWP QPTPWAGGAP PWGPPSSPLP RSARQPWLWV GVAVAVVVAL AGGLGIALAH
      361 PWRSSGPRTS APPPPPPADA VELRVLNDGV FVGSSVAPTT IDIFNEPICP PCGSFIRSYA
      421 SDIDTAVADK QLAVRYHLLN FLDDQSHSKN YSTRAVAASY CVAGQNDPKL YASFYSALFG
      481 SDFQPQENAA SDRTDAELAH LAQTVGAEPT AISCIKSGAD LGTAQTKATN ASETLAGFNA
      541 SGTPFVWDGS MVVNYQDPSW LARLIG
//