LOCUS       SIU00362.1               517 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            PENICILLIN-BINDING PROTEIN protein.
ACCESSION   LT708304-1775
PROTEIN_ID  SIU00362.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1759C"
                     /note="Mb1759c, -, len: 517 aa. Equivalent to Rv1730c,
                     len: 517 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 517 aa overlap). Possible
                     penicillin-binding protein, similar to others e.g.
                     PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4)
                     from Nocardia lactamdurans (381 aa), FASTA scores: opt:
                     643, E(): 3.8e-32, (33.8% identity in 370 aa overlap);
                     etc. Also similar to other Mycobacterium tuberculosis
                     hypothetical penicillin binding proteins and esterases
                     e.g. Rv1923, Rv1497, etc. Protein product from Mb1759c
                     detected using SWATH mass spectrometry. Mb1759c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="InterPro:IPR001466"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ52"
BEGIN
        1 MCPPIILSSA TPTGTRCGTR HGRAVVTEYV RALDRLPHEI ATAVVETVNC ADPGAAFDEL
       61 DAKINAGMKA YAIPGVAVAV WAGGQEYVKG YGVTNVDHPM PVDGDTVFRI GSTTKTFTGT
      121 VMMRLVERGK VDLDSPVRRY IPDFAVADES ASATVTVRQL LNHTAGWDGR NGQDFGRGDD
      181 AVALYVKAMT RLPQLTPPGT AFAYNNSGLV VAGRIIELVA GTTYESTVQR LLLDPLQLAH
      241 TRYFSDQIIG LNVAASHSVV DGKPIAVTDF WTFPRSCNPT GGLMSTARDQ LRYAQFHLGD
      301 GRAPNGEQIL SRQSLKAMRS NPGAGGTLWV ELTGMGVTWM LRPSAENVTI VEHGGTWKGQ
      361 RSGFVMVPDR NFAMTVLTNS DGGFHMINDL FASDWALQRF AGLSNLPATP QRLGAVDLAP
      421 YEGRYIAKQV AQNGDLETTV IDFRARDGQL AGSMSTDDAN PDGQNSANLG LAFYRPDYGL
      481 DLGPDNKPTG SRSNFVRGPD GNIAWFCSQH GRLFRRQ
//