LOCUS       SIU00346.1               187 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            3-HYDROXYBUTYRYL-COA DEHYDROGENASE FADB3a [FIRST PART]
            (BETA-HYDROXYBUTYRYL-COA DEHYDROGENASE) (BHBD) protein.
ACCESSION   LT708304-1759
PROTEIN_ID  SIU00346.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadB3a"
                     /locus_tag="BQ2027_MB1742"
                     /note="Mb1742, fadB3a, len: 187 aa. Equivalent to the 5'
                     end of Rv1715, len: 304 aa, from Mycobacterium
                     tuberculosis strain H37Rv, (100% identity in 187 aa
                     overlap). Probable fadB3, 3-hydroxybutyryl-CoA
                     dehydrogenase (EC 1.1.1.157), highly similar to many e.g.
                     NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase
                     from Mesorhizobium loti (309 aa); NP_250319.1|NC_002516
                     probable 3-hydroxyacyl-CoA dehydrogenase from Pseudomonas
                     aeruginosa (509 aa); P45856|HBD_BACSU PROBABLE
                     3-HYDROXYBUTYRYL-COA DEHYDROGENASE from Bacillus subtilis
                     (287 aa), FASTA scores: opt: 488, E(): 1.5e-24, (38.7%
                     identity in 279 aa overlap); etc. COULD BELONG TO THE
                     3-HYDROXYACYL-COA DEHYDROGENASE FAMILY.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv1715/fadB3 exists as a single
                     gene. In Mycobacterium bovis, a single base transition
                     (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b. Mb1742
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XZG8"
                     /db_xref="InterPro:IPR006176"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZG8"
BEGIN
        1 MLTSHGFSRA AVVGAGLMGR RIAGVLASAG LDVAITDTNA EILHAAAVEA ARVAGAGRGS
       61 VAAAADLAAA IPDADLVIEA VVENLAVKQE LFERLATLAP DAVLATNTSV LPIGAVTERV
      121 EDGSRVIGTH FWNPPDLIPV VEVVPSARTA PDTADRVVAL LTQVGKLPVR VGRDVPGFIG
      181 NRLQHAL
//