LOCUS SIU00342.1 254 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 LSU rRNA pseudouridine(2605) synthase (EC protein. ACCESSION LT708304-1755 PROTEIN_ID SIU00342.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1738" /EC_number="5.4.99.22" /note="Mb1738, -, len: 254 aa. Equivalent to Rv1711, len: 254 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 254 aa overlap). Conserved hypothetical protein, highly similar to a large family of hypothetical proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 aa), FASTA scores: opt: 496, E(): 1.1e-29, (41.6% identity in 250 aa overlap); 9S232|SCI51.08C|AL109848 PUTATIVE PSEUDOURIDINE SYNTHASE from Streptomyces coelicolor (371 aa), FASTA scores: opt: 818, E(): 0, (53.1% identity in 245 aa overlap). Equivalent to O05668|MLCB1351.03C|Z95117 Hypothetical protein from Mycobacterium leprae (256 aa), (80.5% identity in 256 aa overlap). Contains PS01149 Hypothetical yciL/yejD/yjbC family signature. Protein product from Mb1738 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1738 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P65843" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="InterPro:IPR042092" /db_xref="UniProtKB/Swiss-Prot:P65843" BEGIN 1 MMAEPEESRE PRGIRLQKVL SQAGIASRRA AEKMIVDGRV EVDGHVVTEL GTRVDPQVAV 61 VRVDGARVVL DDSLVYLALN KPRGMHSTMS DDRGRPCIGD LIERKVRGTK KLFHVGRLDA 121 DTEGLMLLTN DGELAHRLMH PSHEVPKTYL ATVTGSVPRG LGRTLRAGIE LDDGPAFVDD 181 FAVVDAIPGK TLVRVTLHEG RNRIVRRLLA AAGFPVEALV RTDIGAVSLG KQRPGSVRAL 241 RSNEIGQLYQ AVGL //