LOCUS       SIU00339.1               318 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PUTATIVE
            INITIATION INHIBITOR PROTEIN protein.
ACCESSION   LT708304-1752
PROTEIN_ID  SIU00339.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1735"
                     /note="Mb1735, -, len: 318 aa. Equivalent to Rv1708, len:
                     318 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 318 aa overlap). Putative initiation
                     inhibitor protein, a soj-related protein probably involved
                     in cell process, highly similar to many sporulation
                     initiation inhibitor proteins soj e.g. P37522|SOJ_BACSU
                     Soj protein from Bacillus subtilis (253 aa), FASTA scores:
                     opt: 745, E(): 0, (46.0% identity in 248 aa overlap), and
                     more weakly to various repA/para/incC proteins from
                     various organisms e.g. Y4CK_RHISN|P55393 putative
                     replication protein A from Rhizobium sp. (407 aa), FASTA
                     scores: opt: 205, E(): 4e-13, (29.0% identity in 252 aa
                     overlap). Also similar to Mycobacterium tuberculosis
                     hyothetical proteins Rv3213c and Rv3918c. Protein product
                     from Mb1735 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1735 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR025669"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ37"
BEGIN
        1 MPAGLPGQAS VAVRLSCDVP PDARHHEPRP GMTDHPDTGN GIGLTGRPPR AIPDPTPRSS
       61 HGPAKVIAMC NQKGGVGKTT STINLGAALG EYGRRVLLVD MDPQGALSAG LGVPHYELDK
      121 TIHNVLVEPR VSIDDVLIHS RVKNMDLVPS NIDLSAAEIQ LVNEVGREQT LARALYPVLD
      181 RYDYVLIDCQ PSLGLLTVNG LACTDGVIIP TECEFFSLRG LALLTDTVDK VRDRLNPKLD
      241 ISGILITRYD PRTVNSREVM ARVVERFGDL VFDTVITRTV RFPETSVAGE PITTWAPKSA
      301 GALAYRALAR ELIDRFGM
//