LOCUS       SIU00333.1               196 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            catechol-o-methyltransferase protein.
ACCESSION   LT708304-1746
PROTEIN_ID  SIU00333.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1729C"
                     /note="Mb1729c, -, len: 196 aa. Equivalent to Rv1703c,
                     len: 196 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 196 aa overlap). Probable
                     catechol-o-methyltransferase (EC 2.1.1.6), most similar to
                     COMT_HUMAN|P21964 soluble form of mammalian catechol
                     o-methyltransferase (271 aa), FASTA scores: opt: 405, E():
                     7 .8e-29, (38.9% identity in 190 aa overlap). Also similar
                     to Mycobacterium tuberculosis hypothetical
                     methyltransferases Rv0187, Rv1220c. Protein product from
                     Mb1729c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb1729c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y172"
                     /db_xref="InterPro:IPR002935"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y172"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MLATIDKFAY EKSMLINVGD EKGTLLDAAV RRADPALALE LGTYLGYGAL RIARAAPEAR
       61 VYSVELAEAN ASNARRIWAH AGVDDRVVCV VGTIGDGGRT LDALTEHGFA TGTLDFVFLD
      121 HDKKAYLPDL QSILDRGWLH PGSIVVADNV RVPGAPKYRA YMRRQQGMSW NTIEHKTHLE
      181 YQTLVPDLVL ESEYLG
//