LOCUS       SIU00325.1               307 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 inorganic
            polyphosphate/atp-nad kinase ppnk (poly(p)/atp nad kinase)
            protein.
ACCESSION   LT708304-1738
PROTEIN_ID  SIU00325.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ppnK"
                     /locus_tag="BQ2027_MB1721"
                     /note="Mb1721, ppnK, len: 307 aa. Equivalent to Rv1695,
                     len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 307 aa overlap). Probable ppnK,
                     inorganic polyphosphate/ATP-NAD kinase (EC 2.7.1.23),
                     equivalent to Q49897|MLC1351.13C|Z95117|PPNK_MYCLE
                     INORGANIC POLYPHOSPHATE/ATP-NAD KINASE from Mycobacterium
                     leprae (311 aa) (87.9% identity in 305 aa overlap). Also
                     similar to many e.g. P37768|PPNK_ECOLI PROBABLE INORGANIC
                     POLYPHOSPHATE/ATP-NAD KINASE (292 aa), FASTA scores: opt:
                     384, E(): 1.7e-23, (33.5% identity in 233 aa overlap);
                     etc. BELONGS TO THE NAD KINASE FAMILY. Protein product
                     from Mb1721 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1721 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5S7"
                     /db_xref="InterPro:IPR002504"
                     /db_xref="InterPro:IPR016064"
                     /db_xref="InterPro:IPR017437"
                     /db_xref="InterPro:IPR017438"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5S7"
BEGIN
        1 MTAHRSVLLV VHTGRDEATE TARRVEKVLG DNKIALRVLS AEAVDRGSLH LAPDDMRAMG
       61 VEIEVVDADQ HAADGCELVL VLGGDGTFLR AAELARNASI PVLGVNLGRI GFLAEAEAEA
      121 IDAVLEHVVA QDYRVEDRLT LDVVVRQGGR IVNRGWALNE VSLEKGPRLG VLGVVVEIDG
      181 RPVSAFGCDG VLVSTPTGST AYAFSAGGPV LWPDLEAILV VPNNAHALFG RPMVTSPEAT
      241 IAIEIEADGH DALVFCDGRR EMLIPAGSRL EVTRCVTSVK WARLDSAPFT DRLVRKFRLP
      301 VTGWRGK
//