LOCUS       SIU00307.1               182 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED LIPOPROTEIN DSBF protein.
ACCESSION   LT708304-1720
PROTEIN_ID  SIU00307.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dsbF"
                     /locus_tag="BQ2027_MB1704"
                     /note="Mb1704, dsbF, len: 182 aa. Equivalent to Rv1677,
                     len: 182 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 182 aa overlap). Probable dsbF,
                     conserved lipoprotein possibly involved in thiol:disulfide
                     interchange. Highly similar to C-terminus of
                     Z74024|MTCY274.09 mpt53 soluble secreted antigen precursor
                     from Mycobacterium tuberculosis (173 aa), FASTA scores:
                     opt: 482, E(): 3.6e-23, (52.8% identity in 142 aa overlap)
                     . Also some similarity to P52237|TIPB_PSEFL
                     THIOL:DISULFIDE INTERCHANGE PROTEIN TIPB PRECURSOR from
                     Pseudomonas fluorescens (178 aa), FASTA scores: opt: 190,
                     E(): 4.4e-05, (28.5% identity in 151 aa overlap); and
                     P33926|DSBE_ECOLI THIOL:DISULFIDE INTERCHANGE PROTEIN from
                     Escherichia coli (185 aa), FASTA scores: opt: 194, E():
                     2.6e-05, (29.1% identity in 175 aa overlap). Contains
                     PS00013 Prokaryotic membrane lipoprotein lipid attachment
                     site and PS00194 Thioredoxin family active site. Protein
                     product from Mb1704 detected using shotgun mass
                     spectrometry. Mb1704 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZ07"
                     /db_xref="InterPro:IPR000866"
                     /db_xref="InterPro:IPR013766"
                     /db_xref="InterPro:IPR017937"
                     /db_xref="InterPro:IPR036249"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ07"
BEGIN
        1 MTHSRLIGAL TVVAIIVTAC GSQPKSQPAV APTGDAAAAT QVPAGQTVPA QLQFSAKTLD
       61 GHDFHGESLL GKPAVLWFWA PWCPTCQGEA PVVGQVAASH PEVTFVGVAG LDQVPAMQEF
      121 VNKYPVKTFT QLADTDGSVW ANFGVTQQPA YAFVDPHGNV DVVRGRMSQD ELTRRVTALT
      181 SR
//