LOCUS SIU00295.1 1017 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Probable polyketide synthase pks9 protein. ACCESSION LT708304-1708 PROTEIN_ID SIU00295.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pks9" /locus_tag="BQ2027_MB1692" /note="Mb1692, pks9, len: 1017 aa. Equivalent to Rv1664, len: 1017 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 1017 aa overlap). Probable pks9, polyketide synthase, similar to OL56_STRAT|Q07017 oleandomycin polyketide synthase, modules 5 and 6 from Streptomyces antibioticus (3519 aa), FASTA scores: opt: 1767, E(): 0, (41.6% identity in 919 aa overlap). Similar to other Mycobacterium tuberculosis probable polyketide synthases e.g. pks6, pks8, etc. Contains PS00012 Phosphopantetheine attachment site. Mb1692 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XYZ5" /db_xref="InterPro:IPR001227" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036736" /db_xref="UniProtKB/TrEMBL:A0A1R3XYZ5" BEGIN 1 MQPTGIAIIG LACRFPTVVS PGDLWDLLRD GREATGSIDN VADFDADFFN LSPREASAMD 61 PRQRLALELT WELLEDAFVV PETLRGQPIA VYLGAMNDDY AVLTLAADRV DHHAFAGTSR 121 AIIANRVSFA FGLRGPSVTI DSGQSSSLVA VHLACESVRT GEAPLAIAGG VHLNLARETA 181 MLEQEFGAVS PSGHTYAFDE RADGYVPGDG GGLVLLKPVQ AALDDGDRIH AIIRGSAVGN 241 AGHSATGLTV PSVAGQVDVI RRAMSGAGVD CHQVHYVEAH GTGTKIGDPI EARALGEIFA 301 ARQRRPVSVG SVKTNIGHTG GAAGIAGLLK AVLAIENAVI PPSLNYVGAP IDLDSLGLRV 361 DTALTPWPVA DEPRRAGVSS FGMGGTNAHV ILEQGPTQSP EIVESVAAAG SNAPVAVPWV 421 LAARSPQALT NQAGRLLAHL TADDGLTALD VGWSLVSTRS VFDHRAVVVG ADRGRLMAGL 481 AGLAAGEPGA GVVVGRARSV GKTVFVFPGQ GSQWLGMGRQ LYGRYSVFAR AFDEVVAVLD 541 GQLRLSVRQV MWGADAGLLE STEFAQPALF VVQVALAALL QDWGVLPDLV MGHSVGEIAA 601 AYVAGALSLV DAARVVAARG RLMQALPAGG VMVAVAASED EVAPLLTEGV CIAAVNAPES 661 VVISGEQAAV GVVVDRLVGL GRRVRRLAVS HAFHSVLMDP MVEEFSKVLA DVCVRAPRIG 721 LVSNVTGQLA GAGYGSPAYW VEHVRKPVRF FDGVGLAESL GARVFVEVGP GAGLEASVAL 781 LARDRPEVES VLAGVGRLFA EGVAVDWSSV FAGLGGRRVE LPTYGFARQR FWLGDNGELS 841 VDQTGKDAGA IARLQSLAPP ELQRQLVELV CFHAAIVLGR KSSHDIDPEC AFQDLGFDSM 901 SGVELRNRLQ MAIGLPGLSL PRTLIFDYPT ASALAECLGQ LLGGQHESSD DESIWQLLKN 961 IPIHQLRRTG LLDKLLLLAG QPEESLAGRT VSDEVIDSLS PEALIGLALD EDENDIR //