LOCUS       SIU00295.1              1017 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            polyketide synthase pks9 protein.
ACCESSION   LT708304-1708
PROTEIN_ID  SIU00295.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pks9"
                     /locus_tag="BQ2027_MB1692"
                     /note="Mb1692, pks9, len: 1017 aa. Equivalent to Rv1664,
                     len: 1017 aa, from Mycobacterium tuberculosis strain
                     H37Rv, (99.8% identity in 1017 aa overlap). Probable pks9,
                     polyketide synthase, similar to OL56_STRAT|Q07017
                     oleandomycin polyketide synthase, modules 5 and 6 from
                     Streptomyces antibioticus (3519 aa), FASTA scores: opt:
                     1767, E(): 0, (41.6% identity in 919 aa overlap). Similar
                     to other Mycobacterium tuberculosis probable polyketide
                     synthases e.g. pks6, pks8, etc. Contains PS00012
                     Phosphopantetheine attachment site. Mb1692 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYZ5"
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR020801"
                     /db_xref="InterPro:IPR020806"
                     /db_xref="InterPro:IPR020841"
                     /db_xref="InterPro:IPR032821"
                     /db_xref="InterPro:IPR036736"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYZ5"
BEGIN
        1 MQPTGIAIIG LACRFPTVVS PGDLWDLLRD GREATGSIDN VADFDADFFN LSPREASAMD
       61 PRQRLALELT WELLEDAFVV PETLRGQPIA VYLGAMNDDY AVLTLAADRV DHHAFAGTSR
      121 AIIANRVSFA FGLRGPSVTI DSGQSSSLVA VHLACESVRT GEAPLAIAGG VHLNLARETA
      181 MLEQEFGAVS PSGHTYAFDE RADGYVPGDG GGLVLLKPVQ AALDDGDRIH AIIRGSAVGN
      241 AGHSATGLTV PSVAGQVDVI RRAMSGAGVD CHQVHYVEAH GTGTKIGDPI EARALGEIFA
      301 ARQRRPVSVG SVKTNIGHTG GAAGIAGLLK AVLAIENAVI PPSLNYVGAP IDLDSLGLRV
      361 DTALTPWPVA DEPRRAGVSS FGMGGTNAHV ILEQGPTQSP EIVESVAAAG SNAPVAVPWV
      421 LAARSPQALT NQAGRLLAHL TADDGLTALD VGWSLVSTRS VFDHRAVVVG ADRGRLMAGL
      481 AGLAAGEPGA GVVVGRARSV GKTVFVFPGQ GSQWLGMGRQ LYGRYSVFAR AFDEVVAVLD
      541 GQLRLSVRQV MWGADAGLLE STEFAQPALF VVQVALAALL QDWGVLPDLV MGHSVGEIAA
      601 AYVAGALSLV DAARVVAARG RLMQALPAGG VMVAVAASED EVAPLLTEGV CIAAVNAPES
      661 VVISGEQAAV GVVVDRLVGL GRRVRRLAVS HAFHSVLMDP MVEEFSKVLA DVCVRAPRIG
      721 LVSNVTGQLA GAGYGSPAYW VEHVRKPVRF FDGVGLAESL GARVFVEVGP GAGLEASVAL
      781 LARDRPEVES VLAGVGRLFA EGVAVDWSSV FAGLGGRRVE LPTYGFARQR FWLGDNGELS
      841 VDQTGKDAGA IARLQSLAPP ELQRQLVELV CFHAAIVLGR KSSHDIDPEC AFQDLGFDSM
      901 SGVELRNRLQ MAIGLPGLSL PRTLIFDYPT ASALAECLGQ LLGGQHESSD DESIWQLLKN
      961 IPIHQLRRTG LLDKLLLLAG QPEESLAGRT VSDEVIDSLS PEALIGLALD EDENDIR
//