LOCUS       SIU00291.1               353 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 chalcone
            synthase pks10 protein.
ACCESSION   LT708304-1704
PROTEIN_ID  SIU00291.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pks10"
                     /locus_tag="BQ2027_MB1688"
                     /note="Mb1688, pks10, len: 353 aa. Equivalent to Rv1660,
                     len: 353 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 353 aa overlap). Possible pks10,
                     chalcone synthase (EC 2.3.1.74), similar to
                     BCSA_BACSU|P54157 putative chalcone synthase from B.
                     subtilis (365 aa), FASTA scores: opt: 701, E(): 0, (33.1%
                     identity in 362 aa overlap). Also similar to M.
                     tuberculosis Rv1665|pks11 polyketide synthase (chalcone
                     synthase); and Rv1372|pks18 polyketide synthase. Other
                     upstream initiation sites are possible but homology
                     suggests this start. Protein product from Mb1688 detected
                     using SWATH mass spectrometry. Mb1688 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:Q7VEV2"
                     /db_xref="InterPro:IPR001099"
                     /db_xref="InterPro:IPR011141"
                     /db_xref="InterPro:IPR012328"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/Swiss-Prot:Q7VEV2"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSVIAGVFGA LPPYRYSQRE LTDSFVSIPD FEGYEDIVRQ LHASAKVNSR HLVLPLEKYP
       61 KLTDFGEANK IFIEKAVDLG VQALAGALDE SGLRPEDLDV LITATVTGLA VPSLDARIAG
      121 RLGLRADVRR VPLFGLGCVA GAAGVARLHD YLRGAPDGVA ALVSVELCSL TYPGYKPTLP
      181 GLVGSALFAD GAAAVVAAGV KRAQDIGADG PDILDSRSHL YPDSLRTMGY DVGSAGFELV
      241 LSRDLAAVVE QYLGNDVTTF LASHGLSTTD VGAWVTHPGG PKIINAITET LDLSPQALEL
      301 TWRSLGEIGN LSSASVLHVL RDTIAKPPPS GSPGLMIAMG PGFCSELVLL RWH
//