LOCUS       SIU00287.1               307 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            Ornithine carbamoyltransferase, anabolic ArgF protein.
ACCESSION   LT708304-1700
PROTEIN_ID  SIU00287.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="argF"
                     /locus_tag="BQ2027_MB1684"
                     /note="Mb1684, argF, len: 307 aa. Equivalent to Rv1656,
                     len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 307 aa overlap). Probable argF,
                     ornithine carbamoyltransferase, anabolic (EC 2.1.3.3) (see
                     citation below), almost identical to OTCA_MYCBO|Q02095
                     ornithine carbamoyltransferase, anabolic from
                     Mycobacterium bovis (307 aa), FASTA scores: opt: 1980,
                     E(): 0, (99.0% identity in 307 aa overlap); contains
                     PS00097 Aspartate and ornithine carbamoyltransferases
                     signature. BELONGS TO THE ATCASES/OTCASES FAMILY. Protein
                     product from Mb1684 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1684 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P0A5M9"
                     /db_xref="InterPro:IPR002292"
                     /db_xref="InterPro:IPR006130"
                     /db_xref="InterPro:IPR006131"
                     /db_xref="InterPro:IPR006132"
                     /db_xref="InterPro:IPR024904"
                     /db_xref="InterPro:IPR036901"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5M9"
BEGIN
        1 MIRHFLRDDD LSPAEQAEVL ELAAELKKDP VSRRPLQGPR GVAVIFDKNS TRTRFSFELG
       61 IAQLGGHAVV VDSGSTQLGR DETLQDTAKV LSRYVDAIVW RTFGQERLDA MASVATVPVI
      121 NALSDEFHPC QVLADLQTIA ERKGALRGLR LSYFGDGANN MAHSLLLGGV TAGIHVTVAA
      181 PEGFLPDPSV RAAAERRAQD TGASVTVTAD AHAAAAGADV LVTDTWTSMG QENDGLDRVK
      241 PFRPFQLNSR LLALADSDAI VLHCLPAHRG DEITDAVMDG PASAVWDEAE NRLHAQKALL
      301 VWLLERS
//