LOCUS SIU00287.1 307 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Probable Ornithine carbamoyltransferase, anabolic ArgF protein. ACCESSION LT708304-1700 PROTEIN_ID SIU00287.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="argF" /locus_tag="BQ2027_MB1684" /note="Mb1684, argF, len: 307 aa. Equivalent to Rv1656, len: 307 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 307 aa overlap). Probable argF, ornithine carbamoyltransferase, anabolic (EC 2.1.3.3) (see citation below), almost identical to OTCA_MYCBO|Q02095 ornithine carbamoyltransferase, anabolic from Mycobacterium bovis (307 aa), FASTA scores: opt: 1980, E(): 0, (99.0% identity in 307 aa overlap); contains PS00097 Aspartate and ornithine carbamoyltransferases signature. BELONGS TO THE ATCASES/OTCASES FAMILY. Protein product from Mb1684 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1684 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A5M9" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="UniProtKB/Swiss-Prot:P0A5M9" BEGIN 1 MIRHFLRDDD LSPAEQAEVL ELAAELKKDP VSRRPLQGPR GVAVIFDKNS TRTRFSFELG 61 IAQLGGHAVV VDSGSTQLGR DETLQDTAKV LSRYVDAIVW RTFGQERLDA MASVATVPVI 121 NALSDEFHPC QVLADLQTIA ERKGALRGLR LSYFGDGANN MAHSLLLGGV TAGIHVTVAA 181 PEGFLPDPSV RAAAERRAQD TGASVTVTAD AHAAAAGADV LVTDTWTSMG QENDGLDRVK 241 PFRPFQLNSR LLALADSDAI VLHCLPAHRG DEITDAVMDG PASAVWDEAE NRLHAQKALL 301 VWLLERS //