LOCUS       SIU00275.1               260 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Possible
            23S rRNA methyltransferase tsnR protein.
ACCESSION   LT708304-1688
PROTEIN_ID  SIU00275.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="tsnR"
                     /locus_tag="BQ2027_MB1671"
                     /note="Mb1671, tsnR, len: 260 aa. Equivalent to Rv1644,
                     len: 260 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 260 aa overlap). Possible tsnR, 23S
                     rRNA methyltransferase (EC 2.1.1.-), similar to several
                     e.g. TSNR_STRLU|P52393 from Streptomyces laurentii (270
                     aa), FASTA scores: opt: 276, E(): 3.6e-11, (27.6% identity
                     in 261 aa overlap). Also similar to M. tuberculosis
                     hypothetical proteins Rv0881, Rv3579c, and Rv0380c.
                     Protein product from Mb1671 detected using SWATH mass
                     spectrometry. Mb1671 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYX1"
                     /db_xref="InterPro:IPR001537"
                     /db_xref="InterPro:IPR013123"
                     /db_xref="InterPro:IPR029026"
                     /db_xref="InterPro:IPR029028"
                     /db_xref="InterPro:IPR029064"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYX1"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MLTERSARVA TAVKLHRHVG RRRAGRFLAE GPNLVAAALA RGLVREVFVT EVAARRHELL
       61 LAAHEASVHL VTERAAKALS DTVTPAGLVA VCDLPATRLE DVLAGSPQLI AVTVEIREPG
      121 NAGTVIRIAD AMGAAAVILA GRSVDPYNGK CLRASTGSIF AIPVVVAPDV GAAIADLRAA
      181 GLQVLATAVD GEMALDDADR LLAEPTAWLF GPEAHGLSAE IAALADHRVH IPMSGGAESL
      241 NVAAAAAICL YESARALGRR
//