LOCUS SIU00251.1 527 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER CYDD protein. ACCESSION LT708304-1664 PROTEIN_ID SIU00251.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="cydD" /locus_tag="BQ2027_MB1647C" /note="Mb1647c, cydD, len: 527 aa. Equivalent to Rv1621c, len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 527 aa overlap). Probable cydD, transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. P94366|CYDC_BACSU TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (567 aa), FASTA scores: opt: 784, E(): 0, (30.1% identity in 535 aa overlap); N-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FASTA scores: opt: 1295, E(): 0, (44.6% identity in 534 aa overlap); etc. Also similar to Q11019|Y07D_MYCTU from Mycobacterium tuberculosis (579 aa), FASTA scores: opt: 530, E(): 6.9e-25, (29.1% identity in 530 aa overlap). Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Mb1647c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XYT5" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="InterPro:IPR039421" /db_xref="UniProtKB/TrEMBL:A0A1R3XYT5" BEGIN 1 MACGVGISGC AIGSAIVLAS IVAGVIDPAN PGMAGLRRWL GPLSILLVLW GLRASIQWLQ 61 ARLAQRGASA VIADLSGQVL TAVTARRPSQ LAAQRDAAAV LITRGLDGLR PYFTGYLPTL 121 LLAAILTPAT VAVIGLYDLK SMAIVVITLP LIPIFMVLIG LATTNPSAAA LAAMTAVQAR 181 LLDLIAGIPT LRALGRASGP EQRIAELSAD HRRSAMATLR IAFLSALVLE LLATLGVALV 241 AVGIGLRLVF GEMSLTAGLT VLLLAPEVYW PLRRVGVQFH AAADGRTAAD KAFALLGESP 301 SPTPGRRTVT ARGGVIRLER LSVRGRDGRA PYDLTADIEP GRVTVLTGRN GAGKSTTLQA 361 IAGLTAPSSG RITVAGVDVT NLAPAAWWRQ LSWLPQRPVL VPGTVRHNLV LLGPVDDLER 421 ACAAAGFDAV LDELPRGLDT VLGRGGVGLS LGQRQRLGLA RALGSPAAVL LLDEPTAHLD 481 ARTEQHVLGA IVERARAGAT VLVVAHRQQV AAAGDRVVEV NSDGFRR //