LOCUS SIU00250.1 576 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE 'COMPONENT LINKED WITH THE ASSEMBLY OF CYTOCHROME' TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER CYDC protein. ACCESSION LT708304-1663 PROTEIN_ID SIU00250.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="cydC" /locus_tag="BQ2027_MB1646C" /note="Mb1646c, cydC, len: 576 aa. Equivalent to Rv1620c, len: 576 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 576 aa overlap). Probable cydC, transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below), similar to others e.g. CYDC_ECOLI|P23886 transport ATP-binding protein from Escherichia coli (573 aa), FASTA scores: opt: 631, E(): 1.6e-30, (28.5% identity in 569 aa overlap); C-terminal part of AL034355|SCD78_14 from Streptomyces coelicolor (1172 aa), FASTA scores: opt: 956, E(): 0, (38.8% identity in 554 aa overlap); etc. Contains (PS00211) ABC transporters family signature, and (PS00017) ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Mb1646c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XYV3" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/TrEMBL:A0A1R3XYV3" BEGIN 1 MNRPSAVSRR QRDLLAASGL LGPRLPRILA AVALGVLSLG SALALAGVSA WLITRAWQMP 61 PVLDLSVAVV AVRAFAISRG VLHYCERLAT HDTALRAAGR ARTLIYHRLA HGPAAAAVGL 121 HSGDLAARVG ADVDELANML VRALVPIAVA AVLAVAATAV VAAVSVPAAV VLAVCLLVAG 181 VVAPWLAGRT AAAQEAIARQ HRGMRDTSAM IALEHAPELR VAGALRNVIA DSQRRQHAWA 241 DALDAAARTG AIAEAMPTAA IGASLLGAVV AGIGMAPTVA PTTLAILMLL PLSAFEATVA 301 LPAAAVQLTR SRIAAARLLD LTGSNRVRET ESTVSARLPV GTGVLAADVC CGHQEAQSIR 361 VTIDLPPGAR LAVTGASGAG KTTLLMTLAG LLPPVHGRVL LDGTNLSDFD EDELRSAVSF 421 FAEDAHIFAT TVRDNLLTAR GDCPDDELIE ALDRVGLCGW LAGLPEGLST VLIGGAQAVS 481 AGQRRRLLLA RAVLSPARIV LLDEPVEHLD AANADLLRDL LAPNSGIMSA MRTVVVATHH 541 LPNDIQCAEL SIATDQRCRR RGTNSSDNNT NASAKT //