LOCUS       SIU00247.1               472 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            pyruvate kinase pykA protein.
ACCESSION   LT708304-1660
PROTEIN_ID  SIU00247.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pykA"
                     /locus_tag="BQ2027_MB1643"
                     /note="Mb1643, pykA, len: 472 aa. Equivalent to Rv1617,
                     len: 472 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 472 aa overlap). Probable pykA,
                     pyruvate kinase (EC 2.7.1.40). FASTA best: Q46078 PYRUVATE
                     KINASE from CORYNEBACTERIUM GLUTAMICUM (475 aa), opt:
                     2221, E(): 0, (72.2% identity in 468 aa overlap). BELONGS
                     TO THE PYRUVATE KINASE FAMILY. Protein product from Mb1643
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1643 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYV1"
                     /db_xref="InterPro:IPR001697"
                     /db_xref="InterPro:IPR011037"
                     /db_xref="InterPro:IPR015793"
                     /db_xref="InterPro:IPR015795"
                     /db_xref="InterPro:IPR015806"
                     /db_xref="InterPro:IPR015813"
                     /db_xref="InterPro:IPR036918"
                     /db_xref="InterPro:IPR040442"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYV1"
BEGIN
        1 MTRRGKIVCT LGPATQRDDL VRALVEAGMD VARMNFSHGD YDDHKVAYER VRVASDATGR
       61 AVGVLADLQG PKIRLGRFAS GATHWAEGET VRITVGACEG SHDRVSTTYK RLAQDAVAGD
      121 RVLVDDGKVA LVVDAVEGDD VVCTVVEGGP VSDNKGISLP GMNVTAPALS EKDIEDLTFA
      181 LNLGVDMVAL SFVRSPADVE LVHEVMDRIG RRVPVIAKLD KPEAIDNLEA IVLAFDAVMV
      241 ARGDLGVELP LEEVPLVQKR AIQMARENAK PVIVATQMLD SMIENSRPTR AEASDVANAV
      301 LDGADALMLS GETSVGKYPL AAVRTMSRII CAVEENSTAA PPLTHIPRTK RGVISYAARD
      361 IGERLDAKAL VAFTQSGDTV RRLARLHTPL PLLAFTAWPE VRSQLAMTWG TETFIVPKMQ
      421 STDGMIRQVD KSLLELARYK RGDLVVIVAG APPGTVGSTN LIHVHRIGED DV
//