LOCUS       SIU00237.1               360 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            ionic transporter integral membrane protein chaA protein.
ACCESSION   LT708304-1650
PROTEIN_ID  SIU00237.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="chaA"
                     /locus_tag="BQ2027_MB1633"
                     /note="Mb1633, chaA, len: 360 aa. Equivalent to Rv1607,
                     len: 360 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 360 aa overlap). Probable chaA, ionic
                     transporter integral membrane protein, putative
                     calcium/proton antiporter, similar to many e.g.
                     P31801|CHAA_ECOLI CALCIUM/PROTON ANTIPORTER from
                     Escherichia coli (366 aa), FASTA scores: opt: 736, E(): 0,
                     (35.9% identity in 351 aa overlap). Equivalent to
                     Mycobacterium leprae AL049913|MLCB1610_21 (77.7% identity
                     in 364 aa overlap). SEEMS TO BELONG TO THE CaCA FAMILY.
                     Protein product from Mb1633 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1633 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XYU2"
                     /db_xref="InterPro:IPR004837"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYU2"
BEGIN
        1 MLKRVPWTVV LPSLAFVALV LTWGKQIGPV VGLLAAVLLA GAVLAAVNHA EVVAARVGEP
       61 FGSLVLAVAV TTIEVALIVA LMVSGGDDAA TLARDTVFAA VMITTNGIAG LSLLLGSLRY
      121 GVTLFNPHGS GAALATVTTL ATLSLVLPTF TTSQSGPELS PGQLIFAGAA SLGLYVLFLF
      181 TQTVRHRDFF LPVAQKGAVE DDSHADPPST RAALLSLGLL LVALVAVVGL AKVESPVIEE
      241 VVSAAGFPQS FVGVVIATLV LLPETLAAAR AARQGRLQTS LNLAYGSAMA SIGLTIPTIA
      301 LASLWLSGPL QLGLGAIQLV LLVLTVVVSV LTVVPGRATR LQGEVHLVLL AAYLFLAVVP
//