LOCUS       SIU00236.1               115 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            phosphoribosyl-AMP 1,6 cyclohydrolase hisI protein.
ACCESSION   LT708304-1649
PROTEIN_ID  SIU00236.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hisI"
                     /locus_tag="BQ2027_MB1632"
                     /note="Mb1632, hisI, len: 115 aa. Equivalent to Rv1606,
                     len: 115 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 115 aa overlap). Probable hisI,
                     phosphoribosyl-AMP 1,6 cyclohydrolase (EC 3.5.4.19),
                     similar to several e.g. X82010|RSHISI_2 HISI from
                     Rhodobacter sphaeroides (119 aa), FASTA scores: opt: 378,
                     E(): 2.8e-21, (52.3% identity in 109 aa overlap); etc.
                     Protein product from Mb1632 detected using SWATH mass
                     spectrometry. Mb1632 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5B4"
                     /db_xref="InterPro:IPR002496"
                     /db_xref="InterPro:IPR026660"
                     /db_xref="InterPro:IPR038019"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5B4"
BEGIN
        1 MTLDPKIAAR LKRNADGLVT AVVQERGSGD VLMVAWMNDE ALARTLQTRE ATYYSRSRAE
       61 QWVKGATSGH TQHVHSVRLD CDGDAVLLTV DQVGGACHTG DHSCFDAAVL LEPDD
//