LOCUS       SIU00235.1               267 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            cyclase hisF protein.
ACCESSION   LT708304-1648
PROTEIN_ID  SIU00235.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hisF"
                     /locus_tag="BQ2027_MB1631"
                     /note="Mb1631, hisF, len: 267 aa. Equivalent to Rv1605,
                     len: 267 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 267 aa overlap). Probable hisF, cyclase
                     involved in histidine biosynthetic pathway, similar to
                     many e.g. AF0304|AF030405_1 Corynebacterium glutamicum
                     cyclase (257 aa), FASTA scores: opt: 1201, E(): 0, (71.9%
                     identity in 256 aa overlap). BELONGS TO THE HISA / HISF
                     FAMILY. Protein product from Mb1631 detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb1631
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:Q7VEW8"
                     /db_xref="InterPro:IPR004651"
                     /db_xref="InterPro:IPR006062"
                     /db_xref="InterPro:IPR011060"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="UniProtKB/Swiss-Prot:Q7VEW8"
BEGIN
        1 MYADRDLPGA GGLAVRVIPC LDVDDGRVVK GVNFENLRDA GDPVELAAVY DAEGADELTF
       61 LDVTASSSGR ATMLEVVRRT AEQVFIPLTV GGGVRTVADV DSLLRAGADK VAVNTAAIAC
      121 LDLLADMARQ FGSQCIVLSV DARTVPVGSA PTPSGWEVTT HGGRRGTGMD AVQWAARGAD
      181 LGVGEILLNS MDADGTKAGF DLALLRAVRA AVTVPVIASG GAGAVEHFAP AVAAGADAVL
      241 AASVFHFREL TIGQVKAALA AEGITVR
//