LOCUS       SIU00233.1               245 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHOSPHORIBOSYLFORMIMINO-5- AMINOIMIDAZOLE CARBOXAMIDE
            RIBOTIDE ISOMERASE HISA protein.
ACCESSION   LT708304-1646
PROTEIN_ID  SIU00233.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hisA"
                     /locus_tag="BQ2027_MB1629"
                     /note="Mb1629, hisA, len: 245 aa. Equivalent to Rv1603,
                     len: 245 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 245 aa overlap). Probable hisA,
                     PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE
                     RIBOTIDE ISOMERASE (EC 5.3.1.16), similar to many e.g.
                     HIS4_STRCO|P16250 phosphoribosylformimino-5-aminoimidaz
                     from Streptomyces coelicolor (240 aa), FASTA scores: opt:
                     1081, E(): 0, (69.0% identity in 239 aa overlap). Protein
                     product from Mb1629 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1629 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P60579"
                     /db_xref="InterPro:IPR006062"
                     /db_xref="InterPro:IPR010188"
                     /db_xref="InterPro:IPR011060"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR023016"
                     /db_xref="UniProtKB/Swiss-Prot:P60579"
BEGIN
        1 MMPLILLPAV DVVEGRAVRL VQGKAGSQTE YGSAVDAALG WQRDGAEWIH LVDLDAAFGR
       61 GSNHELLAEV VGKLDVQVEL SGGIRDDESL AAALATGCAR VNVGTAALEN PQWCARVIGE
      121 HGDQVAVGLD VQIIDGEHRL RGRGWETDGG DLWDVLERLD SEGCSRFVVT DITKDGTLGG
      181 PNLDLLAGVA DRTDAPVIAS GGVSSLDDLR AIATLTHRGV EGAIVGKALY ARRFTLPQAL
      241 AAVRD
//