LOCUS       SIU00226.1               285 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            nicotinate-nucleotide pyrophosphatase nadC protein.
ACCESSION   LT708304-1639
PROTEIN_ID  SIU00226.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nadC"
                     /locus_tag="BQ2027_MB1622"
                     /note="Mb1622, nadC, len: 285 aa. Equivalent to Rv1596,
                     len: 285 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 285 aa overlap). Probable nadC,
                     nicotinate-nucleotide pyrophosphatase (EC 2.4.2.19)
                     O06594. Similar to many e.g. ADC_MYCLE|P46714 from
                     Mycobacterium leprae (284 aa), FASTA results: opt: 1418,
                     E(): 0,(79.2% identity in 283 aa overlap). BELONGS TO THE
                     NADC/MODD FAMILY. Protein product from Mb1622 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1622 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZ55"
                     /db_xref="InterPro:IPR002638"
                     /db_xref="InterPro:IPR004393"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR022412"
                     /db_xref="InterPro:IPR027277"
                     /db_xref="InterPro:IPR036068"
                     /db_xref="InterPro:IPR037128"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZ55"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MGLSDWELAA ARAAIARGLD EDLRYGPDVT TLATVPASAT TTASLVTREA GVVAGLDVAL
       61 LTLDEVLGTN GYRVLDRVED GARVPPGEAL MTLEAQTRGL LTAERTMLNL VGHLSGIATA
      121 TAAWVDAVRG TKAKIRDTRK TLPGLRALQK YAVRTGGGVN HRLGLGDAAL IKDNHVAAAG
      181 SVVDALRAVR NAAPDLPCEV EVDSLEQLDA VLPEKPELIL LDNFAVWQTQ TAVQRRDSRA
      241 PTVMLESSGG LSLQTAATYA ETGVDYLAVG ALTHSVRVLD IGLDM
//