LOCUS SIU00222.1 446 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Lipase 1 (EC protein. ACCESSION LT708304-1635 PROTEIN_ID SIU00222.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1618C" /EC_number="3.1.1.3" /note="Mb1618c, -, len: 446 aa. Equivalent to Rv1592c, len: 446 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 446 aa overlap). Conserved hypothetical protein, some similarity to Q49629|B1170_F1_46 from Mycobacterium leprae (132 aa), FASTA results: opt: 332, E(): 4.5e-14, (56.3% identity in 87 aa overlap). Nearly identical to truncated Mycobacterium bovis BCG protein (148 aa) AF041819|AF041819_11. Protein product from Mb1618c detected using SWATH mass spectrometry. Mb1618c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XYR5" /db_xref="InterPro:IPR005152" /db_xref="InterPro:IPR029058" /db_xref="UniProtKB/TrEMBL:A0A1R3XYR5" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MVEPGNLAGA TGAEWIGRPP HEELQRKVRP LLPSDDPFYF PPAGYQHAVP GTVLRSRDVE 61 LAFMGLIPQP VTATQLLYRT TNMYGNPEAT VTTVIVPAEL APGQTCPLLS YQCAIDAMSS 121 RCFPSYALRR RAKALGSLTQ MELLMISAAL AEGWAVSVPD HEGPKGLWGS PYEPGYRVLD 181 GIRAALNSER VGLSPATPIG LWGYSGGGLA SAWAAEACGE YAPDLDIVGA VLGSPVGDLG 241 HTFRRLNGTL LAGLPALVVA ALQHSYPGLA RVIKEHANDE GRQLLEQLTE MTTVDAVIRM 301 AGRDMGDFLD EPLEDILSTP EVSHVFGDTK LGSAVPTPPV LIVQAVHDYL IDVSDIDALA 361 DSYTAGGANV TYHRDLFSEH VSLHPLSAPM TLRWLTDRFA GKPLTDHRVR TTWPTIFNPM 421 TYAGMARLAV IAAKVITGRK LSRRPL //