LOCUS       SIU00222.1               446 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Lipase
            1 (EC protein.
ACCESSION   LT708304-1635
PROTEIN_ID  SIU00222.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1618C"
                     /EC_number="3.1.1.3"
                     /note="Mb1618c, -, len: 446 aa. Equivalent to Rv1592c,
                     len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 446 aa overlap). Conserved hypothetical
                     protein, some similarity to Q49629|B1170_F1_46 from
                     Mycobacterium leprae (132 aa), FASTA results: opt: 332,
                     E(): 4.5e-14, (56.3% identity in 87 aa overlap). Nearly
                     identical to truncated Mycobacterium bovis BCG protein
                     (148 aa) AF041819|AF041819_11. Protein product from
                     Mb1618c detected using SWATH mass spectrometry. Mb1618c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XYR5"
                     /db_xref="InterPro:IPR005152"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYR5"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MVEPGNLAGA TGAEWIGRPP HEELQRKVRP LLPSDDPFYF PPAGYQHAVP GTVLRSRDVE
       61 LAFMGLIPQP VTATQLLYRT TNMYGNPEAT VTTVIVPAEL APGQTCPLLS YQCAIDAMSS
      121 RCFPSYALRR RAKALGSLTQ MELLMISAAL AEGWAVSVPD HEGPKGLWGS PYEPGYRVLD
      181 GIRAALNSER VGLSPATPIG LWGYSGGGLA SAWAAEACGE YAPDLDIVGA VLGSPVGDLG
      241 HTFRRLNGTL LAGLPALVVA ALQHSYPGLA RVIKEHANDE GRQLLEQLTE MTTVDAVIRM
      301 AGRDMGDFLD EPLEDILSTP EVSHVFGDTK LGSAVPTPPV LIVQAVHDYL IDVSDIDALA
      361 DSYTAGGANV TYHRDLFSEH VSLHPLSAPM TLRWLTDRFA GKPLTDHRVR TTWPTIFNPM
      421 TYAGMARLAV IAAKVITGRK LSRRPL
//