LOCUS SIU00200.1 226 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 dethiobiotin synthetase biod protein. ACCESSION LT708304-1613 PROTEIN_ID SIU00200.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="bioD" /locus_tag="BQ2027_MB1597" /note="Mb1597, bioD, len: 226 aa. Equivalent to Rv1570, len: 226 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 226 aa overlap). Probable bioD, dethiobiotin synthetase (EC 6.3.3.3). Similar to many e.g. BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa), FASTA results: opt: 1059, E(): 0, (74.8% identity in 222 aa overlap). BELONGS TO THE DETHIOBIOTIN SYNTHETASE FAMILY. Protein product from Mb1597 detected using SWATH mass spectrometry. Mb1597 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:O52587" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="UniProtKB/Swiss-Prot:O52587" BEGIN 1 MTILVVTGTG TGVGKTVVCA ALASAARQAG IDVAVCKPVQ TGTARGDDDL AEVGRLAGVT 61 QLAGLARYPQ PMAPAAAAEH AGMALPARDQ IVRLIADLDR PGRLTLVEGA GGLLVELAEP 121 GVTLRDVAVD VAAAALVVVT ADLGTLNHTK LTLEALAAQQ VSCAGLVIGS WPDPPGLVAA 181 SNRSALARIA TVRAALPAGA ASLDAGDFAA MSAAAFDRNW VAGLVG //