LOCUS       SIU00200.1               226 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 dethiobiotin
            synthetase biod protein.
ACCESSION   LT708304-1613
PROTEIN_ID  SIU00200.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="bioD"
                     /locus_tag="BQ2027_MB1597"
                     /note="Mb1597, bioD, len: 226 aa. Equivalent to Rv1570,
                     len: 226 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 226 aa overlap). Probable bioD,
                     dethiobiotin synthetase (EC 6.3.3.3). Similar to many e.g.
                     BIOD_MYCLE|P45486 from Mycobacterium leprae (223 aa),
                     FASTA results: opt: 1059, E(): 0, (74.8% identity in 222
                     aa overlap). BELONGS TO THE DETHIOBIOTIN SYNTHETASE
                     FAMILY. Protein product from Mb1597 detected using SWATH
                     mass spectrometry. Mb1597 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:O52587"
                     /db_xref="InterPro:IPR004472"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="UniProtKB/Swiss-Prot:O52587"
BEGIN
        1 MTILVVTGTG TGVGKTVVCA ALASAARQAG IDVAVCKPVQ TGTARGDDDL AEVGRLAGVT
       61 QLAGLARYPQ PMAPAAAAEH AGMALPARDQ IVRLIADLDR PGRLTLVEGA GGLLVELAEP
      121 GVTLRDVAVD VAAAALVVVT ADLGTLNHTK LTLEALAAQQ VSCAGLVIGS WPDPPGLVAA
      181 SNRSALARIA TVRAALPAGA ASLDAGDFAA MSAAAFDRNW VAGLVG
//