LOCUS SIU00195.1 729 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 O-antigen acetylase protein. ACCESSION LT708304-1608 PROTEIN_ID SIU00195.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1592C" /note="Mb1592c, -, len: 729 aa. Equivalent to Rv1565c, len: 729 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 729 aa overlap). Conserved hypothetical membrane protein, some similarity to O05402 HYPOTHETICAL 72.2 KD PROTEIN from Bacillus subtilis (634 aa), FASTA results: opt: 384, E(): 4.8e-17, (29.1% identity in 378 aa overlap); and to Y392_HAEIN|P43993 hypothetical protein hi0392 from H. influenzae (245 aa), FASTA results: opt: 265, E(): 5.5e-10, (28.3% identity in 247 aa overlap). C-terminal half equivalent to AL049478|MLCL458_19 (274 aa) (78.5% identity in 274 aa overlap). Also similar to M. tuberculosis hypothetical proteins Rv0111, Rv0228, Rv1254, Rv0517. N-terminal half hydrophobic. Protein product from Mb1592c detected using SWATH mass spectrometry. Mb1592c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XYP2" /db_xref="InterPro:IPR002656" /db_xref="UniProtKB/TrEMBL:A0A1R3XYP2" BEGIN 1 MLTLSPPRPP ALTPEPALPP VTMGTRTTGF YRHDLDGLRG VAIALVAVFH VWFGRVSGGV 61 DVFLALSGFF FGGKILRAAL NPDLSLSPIA EVIRLIRRLL PALVVVLAGC ALLTIAIQPQ 121 TRWEAFANQS LASLGYYQNW ELASTVSNYL RAGEAVSPLQ HIWSMSVQGQ FYLAFLLLVA 181 GCAYLLRRLF RGPRAPYLRT MFVVLLSTLT LASFIYAIVA HHAYQATAYY NTFARAWELL 241 AGALVGAVVP HVRWPMWLRT AVATAALAAI LSCGALIDGV KEFPGPWALV PVGATMLMIL 301 AGANRQGHPG TRDRLPLPNR LLATAPLVAL GAMAYSWYLW HWPLLIFWLS YTGHRHANFV 361 EGAAVLLVSG LLAYLTTRLV EDPLRYRAPA GVRSPAAVPP IPWRLRLRRP TIVLGSVVAL 421 LGVALTATSF TWREHVIVQR AAGKELSGLS SRDYPGARAL IDHVRVPKLR MRPTVLEVRH 481 DLPTSTKDGC ISDFVNPAII NCTYGDVDAP RTIALAGGSH AEHWLTALDL LGRMHHFKVV 541 TYLKMGCPLS TEEVPLIMGN NAPYPQCHQW VQAAMAKLVA DHPDYVFTTS TRPWNIKPGD 601 VMPATYVGIW QTFADNNIPV LAMRDTPWLV KDGQPFIPAD CLAKGGNPQS CGIARSKVLV 661 DRNPTLDFVA RFPLLKPLDM SDAICRTDTC RAVEGNVLVY RDSHHLTPTY MRTMTSELGR 721 QIAANTDWW //