LOCUS       SIU00195.1               729 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 O-antigen
            acetylase protein.
ACCESSION   LT708304-1608
PROTEIN_ID  SIU00195.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1592C"
                     /note="Mb1592c, -, len: 729 aa. Equivalent to Rv1565c,
                     len: 729 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 729 aa overlap). Conserved hypothetical
                     membrane protein, some similarity to O05402 HYPOTHETICAL
                     72.2 KD PROTEIN from Bacillus subtilis (634 aa), FASTA
                     results: opt: 384, E(): 4.8e-17, (29.1% identity in 378 aa
                     overlap); and to Y392_HAEIN|P43993 hypothetical protein
                     hi0392 from H. influenzae (245 aa), FASTA results: opt:
                     265, E(): 5.5e-10, (28.3% identity in 247 aa overlap).
                     C-terminal half equivalent to AL049478|MLCL458_19 (274 aa)
                     (78.5% identity in 274 aa overlap). Also similar to M.
                     tuberculosis hypothetical proteins Rv0111, Rv0228, Rv1254,
                     Rv0517. N-terminal half hydrophobic. Protein product from
                     Mb1592c detected using SWATH mass spectrometry. Mb1592c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XYP2"
                     /db_xref="InterPro:IPR002656"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYP2"
BEGIN
        1 MLTLSPPRPP ALTPEPALPP VTMGTRTTGF YRHDLDGLRG VAIALVAVFH VWFGRVSGGV
       61 DVFLALSGFF FGGKILRAAL NPDLSLSPIA EVIRLIRRLL PALVVVLAGC ALLTIAIQPQ
      121 TRWEAFANQS LASLGYYQNW ELASTVSNYL RAGEAVSPLQ HIWSMSVQGQ FYLAFLLLVA
      181 GCAYLLRRLF RGPRAPYLRT MFVVLLSTLT LASFIYAIVA HHAYQATAYY NTFARAWELL
      241 AGALVGAVVP HVRWPMWLRT AVATAALAAI LSCGALIDGV KEFPGPWALV PVGATMLMIL
      301 AGANRQGHPG TRDRLPLPNR LLATAPLVAL GAMAYSWYLW HWPLLIFWLS YTGHRHANFV
      361 EGAAVLLVSG LLAYLTTRLV EDPLRYRAPA GVRSPAAVPP IPWRLRLRRP TIVLGSVVAL
      421 LGVALTATSF TWREHVIVQR AAGKELSGLS SRDYPGARAL IDHVRVPKLR MRPTVLEVRH
      481 DLPTSTKDGC ISDFVNPAII NCTYGDVDAP RTIALAGGSH AEHWLTALDL LGRMHHFKVV
      541 TYLKMGCPLS TEEVPLIMGN NAPYPQCHQW VQAAMAKLVA DHPDYVFTTS TRPWNIKPGD
      601 VMPATYVGIW QTFADNNIPV LAMRDTPWLV KDGQPFIPAD CLAKGGNPQS CGIARSKVLV
      661 DRNPTLDFVA RFPLLKPLDM SDAICRTDTC RAVEGNVLVY RDSHHLTPTY MRTMTSELGR
      721 QIAANTDWW
//