LOCUS       SIU00193.1               250 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Maltooligosyltreh
            alose synthase TreYa [FIRST PART] protein.
ACCESSION   LT708304-1606
PROTEIN_ID  SIU00193.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="treYa"
                     /locus_tag="BQ2027_MB1590C"
                     /standard_name="glgY"
                     /note="Mb1590c, treYa, len: 250 aa. Equivalent to the 5'
                     end of Rv1563c, len: 765 aa, from Mycobacterium
                     tuberculosis strain H37Rv, (97.4% identity in 191 aa
                     overlap). treY (previously called glgY), maltooligosyl
                     trehalose synthase, confirmed biochemically (see citation
                     below). Strong similarity to Q44315|63343 TREY
                     MALTOOLIGOSYL TREHALOSE SYNTHASE from ARTHROBACTER SP (775
                     aa), fasta scores: opt: 1953, E(): 0; (46.0% identity in
                     789 aa overlap). Some similarity to alpha-amylases and to
                     MTCY48.03 (30.2% identity in 215 aa overlap). May catalyse
                     conversion of maltodextrins to maltooligosyl trehaloses.
                     Also similar to Mycobacterium tuberculosis glgB (Rv1326c),
                     treZ (Rv1562c). REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, Rv1563c/treY
                     exists as a single gene. In Mycobacterium bovis, a large
                     deletion of 806 bp splits Rv1563c in two parts, treYa and
                     treYb. Mb1590c found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="GOA:A0A1R3Y0U5"
                     /db_xref="InterPro:IPR006047"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0U5"
BEGIN
        1 MAFPVISTYR VQMRGRSNGF GFTFADAENL LDYLDDLGVS HLYLSPILTA VGGSTHGYDV
       61 TDPTTVSPEL GGSDGLARLS AAARSRGMGL IVDIVPSHVG VGKPEQNAWW WDVLKFGRSS
      121 AYAEFFDIDW ELGDGRIILP LLGSDSDVAN LRVDGDLLRL GDLALPVAPG SGDGTGPAVH
      181 DRQHSVWCGR RGVSSPGRHP CSVVATVHDD TVHPRHQTRR GRACPHRRAV PSAVAVGQVH
      241 RPRPSHCARP
//