LOCUS       SIU00191.1               580 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Maltooligosyltreh
            alose trehalohydrolase TreZ protein.
ACCESSION   LT708304-1604
PROTEIN_ID  SIU00191.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="treZ"
                     /locus_tag="BQ2027_MB1588C"
                     /standard_name="glgZ"
                     /note="Mb1588c, treZ, len: 580 aa. Equivalent to Rv1562c,
                     len: 580 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 580 aa overlap). treZ (previously
                     called glgZ), Maltooligosyltrehalose trehalohydrolase,
                     confirmed biochemically (see citation below). Similar to
                     Q44316|D63343 TREZ MALTOOLIGOSYL TREHALOSE
                     TREHALOHYDROLASE from ARTHROBACTER SP (598 aa), FASTA
                     scores: opt: 2071, E(): 0, (52.2% identity in 582 aa
                     overlap); also similar to 1,4-alpha-glucan branching
                     enzymes e.g. GLGB_BACST|P30538 (639 aa), FASTA scores:
                     opt: 313, E(): 3.8e-13, (27.5% identity in 462 aa
                     overlap). Also similar to Mycobacterium tuberculosis
                     proteins Rv1326c|glgB, and Rv1563c treY (previously glgY).
                     Protein product from Mb1588c detected using SWATH mass
                     spectrometry. Mb1588c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYM9"
                     /db_xref="InterPro:IPR006047"
                     /db_xref="InterPro:IPR012768"
                     /db_xref="InterPro:IPR013783"
                     /db_xref="InterPro:IPR014756"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="InterPro:IPR022567"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYM9"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MPEFRVWAPK PALVRLDVNG AVHAMTRSAD GWWHTTVAAP ADARYGYLLD DDPTVLPDPR
       61 SARQPDGVHA RSQRWEPPGQ FGAARTDTGW PGRSVEGAVI YELHIGTFTT AGTFDAAIEK
      121 LDYLVDLGID FVELMPVNSF AGTRGWGYDG VLWYSVHEPY GGPDGLVRFI DACHTRRLGV
      181 LIDAVFNHLG PSGNYLPRFG PYLSSASNPW GDGINIAGAD SDEVRHYIID CALRWMRDFH
      241 ADGLRLDAVH ALVDTTAVHV LEELANATRW LSGQLGRPLS LIAETDRNDP RLITRPSHGG
      301 YGITAQWNDD IHHAIHTAVS GERQGYYADF GSLATLAYTL RNGYFHAGTY SSFRRRRHGR
      361 ALDTSAIPAT RLLAYTCTHD QVGNRALGDR PSQYLTGGQL AIKAALTLGS PYTAMLFMGE
      421 EWGASSPFQF FCSHPEPELA HSTVAGRKEE FAEHGWAADD IPDPQDPQTF QRCKLNWAEA
      481 GSGEHARLHR FYRDLIALRH NEADLADPWL DHLMVDYDEQ QRWVVMRRGQ LMIACNLGAE
      541 PTCVPVSGEL VLAWESPIIG DNSTELAAYS LAILRAAEPA
//