LOCUS       SIU00182.1               374 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            fumarate reductase [membrane anchor subunit] frdc (fumarate
            dehydrogenase) (fumaric hydrogenase) protein.
ACCESSION   LT708304-1595
PROTEIN_ID  SIU00182.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="frdBC"
                     /locus_tag="BQ2027_MB1579"
                     /note="Mb1579, frdBC, len: 374 aa. Equivalent to Rv1553
                     (frdB) and Rv1554 (frdC), len: 247 aa and len: 126 aa,
                     from Mycobacterium tuberculosis strain H37Rv, (100%
                     identity in 247 aa overlap and 99.2% identity in 126 aa
                     overlap). Probable frdB, fumarate reductase, iron-sulfur
                     subunit (EC 1.3.99.1), highly similar to others e.g.
                     P00364|FRDB_ECOLI fumarate reductase iron-sulfur protein
                     from Escherichia coli strain K12 (243 aa), FASTA scores:
                     opt: 846, E(): 0, (50.0% identity in 242 aa overlap);
                     P20921|FRDB_PROVU FUMARATE REDUCTASE IRON-SULFUR PROTEIN
                     from Proteus vulgaris (245 aa); G64097 fumarate reductase
                     (EC 1.3.99.1) iron-sulfur protein from Haemophilus
                     influenzae (276 aa); etc. Contains PS00198 4Fe-4S
                     ferredoxins, iron-sulfur binding region signature. And
                     probable frdC, fumarate reductase, membrane-anchor subunit
                     (EC 1.3.99.1), highly similar to others e.g.
                     P03805|FRDC_ECOLI fumarate reductase 15 kDa hydrophobic
                     protein from Escherichia coli strain K12 (131 aa), FASTA
                     scores, opt: 268, E(): 3.9e-10, (31.1% identity in 122 aa
                     overlap); NP_458780.1|NC_003198 fumarate reductase complex
                     subunit C; membrane anchor polypeptide from Salmonella
                     enterica subsp. enterica serovar Typhi (131 aa);
                     P20923|FRDC_PROVU FUMARATE REDUCTASE 15 KD HYDROPHOBIC
                     PROTEIN from Proteus vulgaris (131 aa); etc. NOTE THAT
                     FUMARATE REDUCTASE FORMS PART OF AN ENZYME COMPLEX
                     CONTAINING FOUR SUBUNITS: A FLAVOPROTEIN (Rv1552|frdA), AN
                     IRON-SULFUR (Rv1553|frdB), AND TWO HYDROPHOBIC ANCHOR
                     PROTEINS (Rv1554|frdC and Rv1555|frdD).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2
                     genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg)
                     leads to a single product. Mb1579 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYM8"
                     /db_xref="InterPro:IPR003510"
                     /db_xref="InterPro:IPR004489"
                     /db_xref="InterPro:IPR009051"
                     /db_xref="InterPro:IPR012675"
                     /db_xref="InterPro:IPR017896"
                     /db_xref="InterPro:IPR017900"
                     /db_xref="InterPro:IPR025192"
                     /db_xref="InterPro:IPR034804"
                     /db_xref="InterPro:IPR036010"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYM8"
BEGIN
        1 MMDRIVMEVS RYRPEIESAP TFQAYEVPLT REWAVLDGLT YIKDHLDGTL SFRWSCRMGI
       61 CGSSGMTING DPKLACATFL ADYLPGPVRV EPMRNFPVIR DLVVDISDFM AKLPSVKPWL
      121 VRHDEPPVED GEYRQTPAEL DAFKQFSMCI NCMLCYSACP VYALDPDFLG PAAIALGQRY
      181 NLDSRDQGAA DRRDVLAAAD GAWACTLVGE CSTACPKGVD PAGAIQRYKL TAATHALKKL
      241 LFPWGGGRMS AYRQPVERYW WARRRSYLRF MLREISCIFV AWFVLYLVLV LRAVGAGGNS
      301 YQRFLDFSAN PVVVVLNVVA LSFLLLHAVT WFGSAPRAMV IQVRGRRVPA RAVLAGHYAA
      361 WLVVSVIVAW MVLS
//