LOCUS       SIU00173.1               341 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            FATTY ACYL-COA REDUCTASE protein.
ACCESSION   LT708304-1586
PROTEIN_ID  SIU00173.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1570"
                     /note="Mb1570, -, len: 341 aa. Equivalent to Rv1543, len:
                     341 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 341 aa overlap). Possible fatty-acyl CoA
                     reductase (EC 1.2.1.-), highly similar to P94129|U77680
                     FATTY ACYL-COA REDUCTASE ACR1 from Acinetobacter
                     calcoaceticus (295 aa), FASTA scores: opt: 899, E(): 0,
                     (48.5% identity in 293 aa overlap). Also highly similar to
                     acrA1|Rv3391|MTV004.49|NP_217908.1|NC_000962 fatty
                     acyl-CoA reductase from Mycobacterium tuberculosis (650
                     aa). Also highly similar to many oxidoreductases
                     short-chain family. Protein product from Mb1570 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1570 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P66780"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/Swiss-Prot:P66780"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNLGDLTNFV EKPLAAVSNI VNTPNSAGRY RPFYLRNLLD AVQGRNLNDA VKGKVVLITG
       61 GSSGIGAAAA KKIAEAGGTV VLVARTLENL ENVANDIRAI RGNGGTAHVY PCDLSDMDAI
      121 AVMADQVLGD LGGVDILINN AGRSIRRSLE LSYDRIHDYQ RTMQLNYLGA VQLILKFIPG
      181 MRERHFGHIV NVSSVGVQTR APRFGAYIAS KAALDSLCDA LQAETVHDNV RFTTVHMALV
      241 RTPMISPTTI YDKFPTLTPD QAAGVITDAI VHRPRRASSP FGQFAAVADA VNPAVMDRVR
      301 NRAFNMFGDS SAAKGSESQT DTSELDKRSE TFVRATRGIH W
//