LOCUS       SIU00168.1               326 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            L-aparaginase ansA protein.
ACCESSION   LT708304-1581
PROTEIN_ID  SIU00168.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ansA"
                     /locus_tag="BQ2027_MB1565C"
                     /note="Mb1565c, ansA, len: 326 aa. Equivalent to Rv1538c,
                     len: 326 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 326 aa overlap). Probable ansA,
                     L-aparaginase, most similar to ASPG_BACLI|P30363
                     L-asparaginase (322 aa), FASTA scores: opt: 417, E():
                     8.8e-19, (30.9% identity in 314 aa overlap). Contains
                     PS00917 Asparaginase / glutaminase active site signature
                     2. Protein product from Mb1565c detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb1565c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P63628"
                     /db_xref="InterPro:IPR004550"
                     /db_xref="InterPro:IPR006034"
                     /db_xref="InterPro:IPR020827"
                     /db_xref="InterPro:IPR027473"
                     /db_xref="InterPro:IPR027474"
                     /db_xref="InterPro:IPR027475"
                     /db_xref="InterPro:IPR036152"
                     /db_xref="InterPro:IPR037152"
                     /db_xref="InterPro:IPR040919"
                     /db_xref="UniProtKB/Swiss-Prot:P63628"
BEGIN
        1 MGANHVRNDP IMARLTVITT GGTISTTAGP DGVLRPTHCG ATLIAGLDMD SDIEVVDLMA
       61 LDSSKLTPAD WDRIGAAVQE AFRGGADGVV ITHGTDTLEE TALWLDLTYA GSRPVVLTGA
      121 MLSADAPGAD GPANLRDALA VAADPAARDL GVLVSFGGRV LQPLGLHKVA NPDLCGFAGE
      181 SLGFTSGGVR LTRTKTRPYL GDLGAAVAPR VDIVAVYPGS DAVAMDACVA AGARAVVLEA
      241 LGSGNAGAAV IEGVRRHCRD GSDPVVIAVS TRVAGARVGA GYGPGHDLVE AGAVMVPRLP
      301 PSQARVLLMA ALAANSPVAD VIDRWG
//