LOCUS       SIU00160.1               367 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            alcohol dehydrogenase adh protein.
ACCESSION   LT708304-1573
PROTEIN_ID  SIU00160.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="adh"
                     /locus_tag="BQ2027_MB1557"
                     /note="Mb1557, adh, len: 367 aa. Equivalent to Rv1530,
                     len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 367 aa overlap). Probable adh, alcohol
                     dehydrogenase (EC 1.1.1.1), zinc-dependent, similar to
                     many e.g. AE0009|AE000958_23 Archaeoglobus fulgidus
                     section 1 (402 aa), FASTA scores: opt: 423, E(): 1.8e-19,
                     (31.7% identity in 341 aa overlap). Contains PS00059
                     Zinc-containing alcohol dehydrogenases signature. Protein
                     product from Mb1557 detected using SWATH mass
                     spectrometry. Mb1557 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYL6"
                     /db_xref="InterPro:IPR002328"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYL6"
BEGIN
        1 MSDGAVVRAL VLEAPRRLVV RQYRLPRIGD DDALVRVEAC GLCGTDHEQY TGELAGGFAF
       61 VPGHETVGTI AAIGPRAEQR WGVSAGDRVA VEVFQSCRQC ANCRGGEYRR CVRHGLADMY
      121 GFIPVDREPG LWGGYAEYQY LAPDSMVLRV AGDLSPEVAT LFNPLGAGIR WGVTIPETKP
      181 GDVVAVLGPG IRGLCAAAAA KGAGAGFVMV TGLGPRDADR LALAAQFGAD LAVDVAIDDP
      241 VAALTEQTGG LADVVVDVTA KAPAAFAQAI ALARPAGTVV VAGTRGVGSG APGFSPDVVV
      301 FKELRVLGAL GVDATAYRAA LDLLVSGRYP FASLPRRCVR LEGAEDLLAT MAGERDGVPP
      361 IHGVLTP
//