LOCUS SIU00157.1 2108 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Probable polyketide synthase pks5 protein. ACCESSION LT708304-1570 PROTEIN_ID SIU00157.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pks5" /locus_tag="BQ2027_MB1554C" /note="Mb1554c, pks5, len: 2108 aa. Equivalent to Rv1527c, len: 2108 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 2108 aa overlap). Probable pks5, polyketide synthase, highly similar to many e.g. MCAS_MYCBO|Q02251 mycocerosic acid synthase from Mycobacterium bovis (2110 aa), FASTA scores: opt: 6270, E(): 0, (63.6% identity in 2126 aa overlap). Protein product from Mb1554c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1554c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XYL5" /db_xref="InterPro:IPR001227" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR013968" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020807" /db_xref="InterPro:IPR020841" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR032821" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036736" /db_xref="InterPro:IPR042104" /db_xref="UniProtKB/TrEMBL:A0A1R3XYL5" BEGIN 1 MGKERTKTVD RTRVTPVAVI GMGCRLPGGI DSPDRLWEAL LRGDDLVTEI PADRWDIDEY 61 YDPEPGVPGR TDCKWGAYLD NVGDFDPEFF GIGEKEAIAI DPQHRLLLET SWEAMEHGGL 121 TPNQMASRTG VFVGLVHTDY ILVHADNQTF EGPYGNTGTN ACFASGRVAY AMGLQGPAIT 181 VDTACSSGLT AIHLACRSLH DGESDIALAG GVYVMLEPRR FASGSALGML SATGRCHAFD 241 VSADGFVSGE GCVMLALKRL PDALADGDRI LAVIRGTAAN QDGHTVNIAT PSRSAQVAAY 301 REALDVAGVD PATVGMVEAH GPGTPVGDPI EYASLAEVYG NDGPCALASV KTNFGHTQSA 361 AGALGLMKAV LALQHGVVPQ NLHFTALPDK LAAIETNLFV PQEITPWPGA DQETPRRAAV 421 SSYGMTGTNV HAIVEQAPVP APESGAPGDT PATPGIDGAL LFALSASSQD ALRQTAARLA 481 DWVDAQGPEL APADLAYTLA RRRGHRPVRT AVLAATTAEL TEALREVATG ETPYPPAVGQ 541 DDRGPVWVFS GQGSQWAGMG ADLLATEPVF AATIAAIEPL IAAESGFSVT EAMTAPEVVT 601 GIDRVQPTLF AMQVALAATM KSYGVAPGAV IGHSLGESAA AVVAGALCLE DGVRVICRRS 661 ALMTRIAGAG AMASVELPAQ QVLSELMARG VNDAVVAVVA SPQSTVIGGA TQTVRDLVAA 721 WEQRDVLARE VAVDVASHSP QVDPILDELA EALAEISPLQ PEIPYYSATS FDPREEPYCD 781 AYYWVDNLRH TVRFAAAVQA ALEDGYRVFT ELTPHPLLTH AVDQTARSLD MSAAALAGMR 841 REQPLPHGLR ALAGDLYAAG AAVDFAVLYP TGRLINAPLP TWNHRRLLLD DTTRRIAHAN 901 TVAVHPLLGS HVRLPEEPER HVWQGEVGTV TQPWLADHQI HGAAALPGAA YCEMALAAAR 961 AVLGEASEVR DIRFEQMLLL DDETPIGVTA TVEAPGVVPL TVETSHDGRY TRQLAAVLHV 1021 VREADDAPDQ PPQKNIAELL ASHPHKVDGA EVRQWLDKRG HRLGPAFAGL VDAYIAEGAG 1081 DTVLAEVNLP GPLRSQVKAY GVHPVLLDAC FQSVAAHPAV QGMADGGLLL PLGVRRLRSY 1141 GSARHARYCC TTVTACGVGV EADLDVLDEH GAVVLAVRGL QLGTGASQAS ERARVLGERL 1201 LSIEWHEREL PENSHAEPGA WLLISTCDAT DLVAAQLTDA LKVHDAQCTT MSWPQRADHA 1261 AQAARLRDQL GTGGFTGVFV LTAPQTGDPD AESPVRGGEL VKHVVRIARE IPEITAQEPR 1321 LYVLTHNAQA VLSGDRPNLE QGGMRGLLRV IGAEHPHLKA SYVDVDEQTG AESVARQLLA 1381 ASGEDETAWR NDQWYTARLC PAPLRPEERQ TTVVDHAEAG MRLQIRTPGD LQTLEFAALD 1441 RVPPGPGEIE VAVTASSINF ADVLVTFGRY QTLDGRQPQL GTDFAGVVSA VGPGVSELKV 1501 GDRVGGMSPN GCWATFVTCD ARLATRLPEG LTDAQAAAVT TASATAWYGL QDLARIKAGD 1561 KVLIHSATGG VGQAAIAIAR AAGAQIYATA GNEKRRDLLR DMGIEHVYDS RSVEFAEQIR 1621 RDTAGYGVDI VLNSVTGAAQ LAGLKLLALG GRFIEIGKRD IYSNTRLELL PFRRNLAFYG 1681 LDLGLMSVSH PAAVRELLST VYRLTVEGVL PMPQSTHYPL AEAATAIRVM GAAEHTGKLI 1741 LDVPHAGRSS VVLPPEQARV FRSDGSYIIT GGLGGLGLFL AEKMANAGAG RIVLSSRSQP 1801 SQKALETIEL VRAIGSDVVV ECGDIAQPDT ADRLVTAATA TGLPLRGVLH AAAVVEDATL 1861 ANITDELIER DWAPKAYGAW QLHRATADQP LDWFCSFSSA AALVGSPGQG AYAAANSWLD 1921 TFTHWRRAQD LPATSIAWGA WGQIGRAIAF AEQTGDAIAP EEGAYAFETL LRHNRAYSGY 1981 APVIGSPWLT AFAQHSPFAE KFQSLGQNRS GTSKFLAELV DLPREEWPDR LRRLLSKQVG 2041 LILRRTIDTD RLLSEYGLDS LSSQELRARV EAETGIRISA TEINTTVRGL ADLMCDKLAA 2101 DRDAPAPA //