LOCUS       SIU00157.1              2108 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            polyketide synthase pks5 protein.
ACCESSION   LT708304-1570
PROTEIN_ID  SIU00157.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pks5"
                     /locus_tag="BQ2027_MB1554C"
                     /note="Mb1554c, pks5, len: 2108 aa. Equivalent to Rv1527c,
                     len: 2108 aa, from Mycobacterium tuberculosis strain
                     H37Rv, (99.9% identity in 2108 aa overlap). Probable pks5,
                     polyketide synthase, highly similar to many e.g.
                     MCAS_MYCBO|Q02251 mycocerosic acid synthase from
                     Mycobacterium bovis (2110 aa), FASTA scores: opt: 6270,
                     E(): 0, (63.6% identity in 2126 aa overlap). Protein
                     product from Mb1554c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1554c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XYL5"
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR013968"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR018201"
                     /db_xref="InterPro:IPR020801"
                     /db_xref="InterPro:IPR020806"
                     /db_xref="InterPro:IPR020807"
                     /db_xref="InterPro:IPR020841"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR032821"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="InterPro:IPR036736"
                     /db_xref="InterPro:IPR042104"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYL5"
BEGIN
        1 MGKERTKTVD RTRVTPVAVI GMGCRLPGGI DSPDRLWEAL LRGDDLVTEI PADRWDIDEY
       61 YDPEPGVPGR TDCKWGAYLD NVGDFDPEFF GIGEKEAIAI DPQHRLLLET SWEAMEHGGL
      121 TPNQMASRTG VFVGLVHTDY ILVHADNQTF EGPYGNTGTN ACFASGRVAY AMGLQGPAIT
      181 VDTACSSGLT AIHLACRSLH DGESDIALAG GVYVMLEPRR FASGSALGML SATGRCHAFD
      241 VSADGFVSGE GCVMLALKRL PDALADGDRI LAVIRGTAAN QDGHTVNIAT PSRSAQVAAY
      301 REALDVAGVD PATVGMVEAH GPGTPVGDPI EYASLAEVYG NDGPCALASV KTNFGHTQSA
      361 AGALGLMKAV LALQHGVVPQ NLHFTALPDK LAAIETNLFV PQEITPWPGA DQETPRRAAV
      421 SSYGMTGTNV HAIVEQAPVP APESGAPGDT PATPGIDGAL LFALSASSQD ALRQTAARLA
      481 DWVDAQGPEL APADLAYTLA RRRGHRPVRT AVLAATTAEL TEALREVATG ETPYPPAVGQ
      541 DDRGPVWVFS GQGSQWAGMG ADLLATEPVF AATIAAIEPL IAAESGFSVT EAMTAPEVVT
      601 GIDRVQPTLF AMQVALAATM KSYGVAPGAV IGHSLGESAA AVVAGALCLE DGVRVICRRS
      661 ALMTRIAGAG AMASVELPAQ QVLSELMARG VNDAVVAVVA SPQSTVIGGA TQTVRDLVAA
      721 WEQRDVLARE VAVDVASHSP QVDPILDELA EALAEISPLQ PEIPYYSATS FDPREEPYCD
      781 AYYWVDNLRH TVRFAAAVQA ALEDGYRVFT ELTPHPLLTH AVDQTARSLD MSAAALAGMR
      841 REQPLPHGLR ALAGDLYAAG AAVDFAVLYP TGRLINAPLP TWNHRRLLLD DTTRRIAHAN
      901 TVAVHPLLGS HVRLPEEPER HVWQGEVGTV TQPWLADHQI HGAAALPGAA YCEMALAAAR
      961 AVLGEASEVR DIRFEQMLLL DDETPIGVTA TVEAPGVVPL TVETSHDGRY TRQLAAVLHV
     1021 VREADDAPDQ PPQKNIAELL ASHPHKVDGA EVRQWLDKRG HRLGPAFAGL VDAYIAEGAG
     1081 DTVLAEVNLP GPLRSQVKAY GVHPVLLDAC FQSVAAHPAV QGMADGGLLL PLGVRRLRSY
     1141 GSARHARYCC TTVTACGVGV EADLDVLDEH GAVVLAVRGL QLGTGASQAS ERARVLGERL
     1201 LSIEWHEREL PENSHAEPGA WLLISTCDAT DLVAAQLTDA LKVHDAQCTT MSWPQRADHA
     1261 AQAARLRDQL GTGGFTGVFV LTAPQTGDPD AESPVRGGEL VKHVVRIARE IPEITAQEPR
     1321 LYVLTHNAQA VLSGDRPNLE QGGMRGLLRV IGAEHPHLKA SYVDVDEQTG AESVARQLLA
     1381 ASGEDETAWR NDQWYTARLC PAPLRPEERQ TTVVDHAEAG MRLQIRTPGD LQTLEFAALD
     1441 RVPPGPGEIE VAVTASSINF ADVLVTFGRY QTLDGRQPQL GTDFAGVVSA VGPGVSELKV
     1501 GDRVGGMSPN GCWATFVTCD ARLATRLPEG LTDAQAAAVT TASATAWYGL QDLARIKAGD
     1561 KVLIHSATGG VGQAAIAIAR AAGAQIYATA GNEKRRDLLR DMGIEHVYDS RSVEFAEQIR
     1621 RDTAGYGVDI VLNSVTGAAQ LAGLKLLALG GRFIEIGKRD IYSNTRLELL PFRRNLAFYG
     1681 LDLGLMSVSH PAAVRELLST VYRLTVEGVL PMPQSTHYPL AEAATAIRVM GAAEHTGKLI
     1741 LDVPHAGRSS VVLPPEQARV FRSDGSYIIT GGLGGLGLFL AEKMANAGAG RIVLSSRSQP
     1801 SQKALETIEL VRAIGSDVVV ECGDIAQPDT ADRLVTAATA TGLPLRGVLH AAAVVEDATL
     1861 ANITDELIER DWAPKAYGAW QLHRATADQP LDWFCSFSSA AALVGSPGQG AYAAANSWLD
     1921 TFTHWRRAQD LPATSIAWGA WGQIGRAIAF AEQTGDAIAP EEGAYAFETL LRHNRAYSGY
     1981 APVIGSPWLT AFAQHSPFAE KFQSLGQNRS GTSKFLAELV DLPREEWPDR LRRLLSKQVG
     2041 LILRRTIDTD RLLSEYGLDS LSSQELRARV EAETGIRISA TEINTTVRGL ADLMCDKLAA
     2101 DRDAPAPA
//