LOCUS       SIU00152.1              1107 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL12 protein.
ACCESSION   LT708304-1565
PROTEIN_ID  SIU00152.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmpL12"
                     /locus_tag="BQ2027_MB1549C"
                     /note="Mb1549c, mmpL12, len: 1107 aa. Equivalent to
                     Rv1522c, len: 1146 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.7% identity in 1107 aa overlap).
                     Probable mmpL12, conserved transmembrane transport protein
                     (see first citation below), member of RND superfamily.
                     Strong similarity to many Mycobacterial membrane proteins
                     e.g. Q49619|G466786 putative transport protein
                     B1170_C1_181 from Mycobacterium leprae (1008 aa), FASTA
                     scores: opt: 2418, E(): 0, (51.0% identity in 1006 aa
                     overlap); etc. Also highly similar to
                     MmpL8|MTCY48.08c|Rv3823c PROBABLE CONSERVED TRANSMEMBRANE
                     TRANSPORT PROTEIN from Mycobacterium tuberculosis, FASTA
                     score: (34.3% identity in 376 aa overlap); and some
                     similarity to MmpL10|MTCY20G9|Rv1183 PROBABLE CONSERVED
                     TRANSMEMBRANE TRANSPORT PROTEIN, FASTA score: (27.2%
                     identity in 1011 aa overlap). BELONGS TO THE MMPL FAMILY.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     single base transversion (c-a) omitting a stop codon,
                     leads to a shorter product compared to its homolog in
                     Mycobacterium tuberculosis strain H37Rv (1107 aa versus
                     1146 aa). Protein product from Mb1549c detected using
                     shotgun mass spectrometry. Mb1549c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XYJ9"
                     /db_xref="InterPro:IPR000731"
                     /db_xref="InterPro:IPR004707"
                     /db_xref="InterPro:IPR004869"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYJ9"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MARHDEAKAG GLFDRIGNFV VRWPLIVIGC WIAVAAALTL LLPTLQAQAA KREQAPLPPG
       61 APSMVLQKEM SAAFQEKIET SALLLVLLTN ENGLGPADEA VYRKLIENLR ADTQDKISVQ
      121 DFLAVPEMKE LLASKDNKAW NLPITFAGDA ASPETQAAFK RVAAIVKQTV AGTSLTVHLS
      181 GPIATVADLT ELGEKDVRII EIGAAVSVLI ILILVYRNLV TMLVPLATIG ASVVTAQGTL
      241 SGLAEFGLAV NMQAIVFMSA VMIGAGTDYA VFLISRYHDY VRHGEKSDMA VKKALMSIGK
      301 VITASAATVA VTFLAMVFTK LEVFSAVGPA IAVAITVSLL GAVTLLPAIL TLTGRRGWIK
      361 PRRDLTSRMW RRSGVRIVRR PTIHLVGSLI VLVALAGCTL LIRFNYDDLK TVPQHVESVK
      421 GYEAMNRHFP MNAMTPMVLF IKSPRDLRTP GALADIEMMS REIAELPNIV MVRGLTRPNG
      481 EPLKETKVSF QAGEVGGKLD EATTLLEEHG GELDQLTGGA HQLADALAQI RNEINGAVAS
      541 SSGIVNTLQA MMDLMGGDKT IRQLENASQY VGRMRALGDN LSGTVTDAEQ IATWASPMVN
      601 ALNSSPVCNS DPACRTSRAQ LAAIVQAQDD GLLRSIRALA VTLQQTQEYQ TLARTVSTLD
      661 GQLKQVVSTL KAVDGLPTKL AQMQQGANAL ADGSAALAAG VQELVDQVKK MGSGLNEAAD
      721 FLLGIKRDAD KPSMAGFNIP PQIFSRDEFK KGAQIFLSAD GHAARYFVQS ALNPATTEAM
      781 DQVNDILRVA DSARPNTELE DATIGLAGVP TALRDIRDYY NSDMKFIVIA TIVIVFLILV
      841 ILLRALVAPI YLIGSVLISY LSALGIGTLV FQLILGQEMH WSLPGLSFIL LVAIGADYNM
      901 LLISRIRDES PHGIRIGVIR TVGSTGGVIT SAGLIFAASM FGLVGANINT MAQAGFTIGI
      961 GIVLDTFLVR TVTVPALTTM IGRANWWPSE LGRDPSTPPT KADRWLRRVK GHRRKAPIPA
     1021 PKPPHTKVVR NTNGHASKAA TKSVPNGKPA DLAEGNGEYL IDHLRRHSLP LFGYAAMPAY
     1081 DVVDGVSKPN GDGAHIGKEP VDHLLGH
//