LOCUS SIU00152.1 1107 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL12 protein. ACCESSION LT708304-1565 PROTEIN_ID SIU00152.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mmpL12" /locus_tag="BQ2027_MB1549C" /note="Mb1549c, mmpL12, len: 1107 aa. Equivalent to Rv1522c, len: 1146 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 1107 aa overlap). Probable mmpL12, conserved transmembrane transport protein (see first citation below), member of RND superfamily. Strong similarity to many Mycobacterial membrane proteins e.g. Q49619|G466786 putative transport protein B1170_C1_181 from Mycobacterium leprae (1008 aa), FASTA scores: opt: 2418, E(): 0, (51.0% identity in 1006 aa overlap); etc. Also highly similar to MmpL8|MTCY48.08c|Rv3823c PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN from Mycobacterium tuberculosis, FASTA score: (34.3% identity in 376 aa overlap); and some similarity to MmpL10|MTCY20G9|Rv1183 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN, FASTA score: (27.2% identity in 1011 aa overlap). BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base transversion (c-a) omitting a stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Protein product from Mb1549c detected using shotgun mass spectrometry. Mb1549c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XYJ9" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004707" /db_xref="InterPro:IPR004869" /db_xref="UniProtKB/TrEMBL:A0A1R3XYJ9" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MARHDEAKAG GLFDRIGNFV VRWPLIVIGC WIAVAAALTL LLPTLQAQAA KREQAPLPPG 61 APSMVLQKEM SAAFQEKIET SALLLVLLTN ENGLGPADEA VYRKLIENLR ADTQDKISVQ 121 DFLAVPEMKE LLASKDNKAW NLPITFAGDA ASPETQAAFK RVAAIVKQTV AGTSLTVHLS 181 GPIATVADLT ELGEKDVRII EIGAAVSVLI ILILVYRNLV TMLVPLATIG ASVVTAQGTL 241 SGLAEFGLAV NMQAIVFMSA VMIGAGTDYA VFLISRYHDY VRHGEKSDMA VKKALMSIGK 301 VITASAATVA VTFLAMVFTK LEVFSAVGPA IAVAITVSLL GAVTLLPAIL TLTGRRGWIK 361 PRRDLTSRMW RRSGVRIVRR PTIHLVGSLI VLVALAGCTL LIRFNYDDLK TVPQHVESVK 421 GYEAMNRHFP MNAMTPMVLF IKSPRDLRTP GALADIEMMS REIAELPNIV MVRGLTRPNG 481 EPLKETKVSF QAGEVGGKLD EATTLLEEHG GELDQLTGGA HQLADALAQI RNEINGAVAS 541 SSGIVNTLQA MMDLMGGDKT IRQLENASQY VGRMRALGDN LSGTVTDAEQ IATWASPMVN 601 ALNSSPVCNS DPACRTSRAQ LAAIVQAQDD GLLRSIRALA VTLQQTQEYQ TLARTVSTLD 661 GQLKQVVSTL KAVDGLPTKL AQMQQGANAL ADGSAALAAG VQELVDQVKK MGSGLNEAAD 721 FLLGIKRDAD KPSMAGFNIP PQIFSRDEFK KGAQIFLSAD GHAARYFVQS ALNPATTEAM 781 DQVNDILRVA DSARPNTELE DATIGLAGVP TALRDIRDYY NSDMKFIVIA TIVIVFLILV 841 ILLRALVAPI YLIGSVLISY LSALGIGTLV FQLILGQEMH WSLPGLSFIL LVAIGADYNM 901 LLISRIRDES PHGIRIGVIR TVGSTGGVIT SAGLIFAASM FGLVGANINT MAQAGFTIGI 961 GIVLDTFLVR TVTVPALTTM IGRANWWPSE LGRDPSTPPT KADRWLRRVK GHRRKAPIPA 1021 PKPPHTKVVR NTNGHASKAA TKSVPNGKPA DLAEGNGEYL IDHLRRHSLP LFGYAAMPAY 1081 DVVDGVSKPN GDGAHIGKEP VDHLLGH //