LOCUS       SIU00137.1               429 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ESTERASE LIPL protein.
ACCESSION   LT708304-1550
PROTEIN_ID  SIU00137.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lipL"
                     /locus_tag="BQ2027_MB1534"
                     /note="Mb1534, lipL, len: 429 aa. Equivalent to Rv1497,
                     len: 429 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 429 aa overlap). Probable LipL, esterase
                     (EC 3.1.-.-), very similar to Mycobacterium tuberculosis
                     hypothetical esterases and penicillin binding proteins
                     e.g. Rv1923, Rv2463, Rv3775, etc. Also similar to
                     G151214|M68491 esterase estA from Pseudomonas sp (389 aa),
                     FASTA scores: opt: 604, E(): 1e-31, (34.4% identity in 389
                     aa overlap). Protein product from Mb1534 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1534 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="InterPro:IPR001466"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYJ7"
BEGIN
        1 MMVDTGVDHR AVSSHDGPDA GRRVFGAADP RFACVVRAFA SMFPGRRFGG GALAVYLDGQ
       61 PVVDVWKGWA DRAGWVPWSA DSAPMVFSAT KGMTATVIHR LADRGLIDYE APVAEYWPAF
      121 GANGKATLTV RDVMRHQAGL SGLRGATQQD LLDHVVMEER LAAAVPGRLL GKSAYHALTF
      181 GWLMSGLARA VTGKDMRLLF REELAEPLDT DGLHLGRPPA DAPTRVAEII MPQDIAANAV
      241 LTCAMRRLAH RFSGGFRSMY FPGAIAAVQG EAPLLDAEIP AANGVATARA LARMYGAIAN
      301 GGEIDGIRFL SRELVTGLTR NRRQVLPDRN LLVPLNFHLG YHGMPIGNVM PGFGHVGLGG
      361 SIGWTDPETG VAFALVHNRL LSPLVMTDHA GFVGIYHLIR QAAAQARKRG YQPVTPFGAP
      421 YSEPGAAAG
//