LOCUS       SIU00133.1               750 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            METHYLMALONYL-COA MUTASE LARGE SUBUNIT MUTB (MCM) protein.
ACCESSION   LT708304-1546
PROTEIN_ID  SIU00133.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mutB"
                     /locus_tag="BQ2027_MB1530"
                     /note="Mb1530, mutB, len: 750 aa. Equivalent to Rv1493,
                     len: 750 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 750 aa overlap). Probable mutB,
                     Methylmalonyl-coa mutase large-subunit (EC 5.4.99.2),
                     strong similarity to e.g. MUTB_STRCM|Q05065
                     methylmalonyl-coa mutase alpha-subunit from Streptomyces
                     cinnamonensis (733 aa), FASTA scores: opt: 3562, E(): 0,
                     (75.8% identity in 730 aa overlap). Contains PS00544
                     Methylmalonyl-CoA mutase signature. BELONGS TO THE
                     METHYLMALONYL-COA MUTASE FAMILY. Protein product from
                     Mb1530 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb1530 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P65488"
                     /db_xref="InterPro:IPR006098"
                     /db_xref="InterPro:IPR006099"
                     /db_xref="InterPro:IPR006158"
                     /db_xref="InterPro:IPR006159"
                     /db_xref="InterPro:IPR016176"
                     /db_xref="InterPro:IPR036724"
                     /db_xref="UniProtKB/Swiss-Prot:P65488"
BEGIN
        1 MTTKTPVIGS FAGVPLHSER AAQSPTEAAV HTHVAAAAAA HGYTPEQLVW HTPEGIDVTP
       61 VYIAADRAAA EAEGYPLHSF PGEPPFVRGP YPTMYVNQPW TIRQYAGFST AADSNAFYRR
      121 NLAAGQKGLS VAFDLATHRG YDSDHPRVQG DVGMAGVAID SILDMRQLFD GIDLSTVSVS
      181 MTMNGAVLPI LALYVVAAEE QGVAPEQLAG TIQNDILKEF MVRNTYIYPP KPSMRIISDI
      241 FAYTSAKMPK FNSISISGYH IQEAGATADL ELAYTLADGV DYIRAGLNAG LDIDSFAPRL
      301 SFFWGIGMNF FMEVAKLRAG RLLWSELVAQ FAPKSAKSLS LRTHSQTSGW SLTAQDVFNN
      361 VARTCIEAMA ATQGHTQSLH TNALDEALAL PTDFSARIAR NTQLVLQQES GTTRPIDPWG
      421 GSYYVEWLTH RLARRARAHI AEVAEHGGMA QAISDGIPKL RIEEAAARTQ ARIDSGQQPV
      481 VGVNKYQVPE DHEIEVLKVE NSRVRAEQLA KLQRLRAGRD EPAVRAALAE LTRAAAEQGR
      541 AGADGLGNNL LALAIDAARA QATVGEISEA LEKVYGRHRA EIRTISGVYR DEVGKAPNIA
      601 AATELVEKFA EADGRRPRIL IAKMGQDGHD RGQKVIATAF ADIGFDVDVG SLFSTPEEVA
      661 RQAADNDVHV IGVSSLAAGH LTLVPALRDA LAQVGRPDIM IVVGGVIPPG DFDELYAAGA
      721 TAIFPPGTVI ADAAIDLLHR LAERLGYTLD
//