LOCUS       SIU00132.1               615 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            METHYLMALONYL-COA MUTASE SMALL SUBUNIT MUTA (MCM) protein.
ACCESSION   LT708304-1545
PROTEIN_ID  SIU00132.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mutA"
                     /locus_tag="BQ2027_MB1529"
                     /note="Mb1529, mutA, len: 615 aa. Equivalent to Rv1492,
                     len: 615 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 615 aa overlap). Probable mutA,
                     Methylmalonyl-coa mutase small-subunit (EC 5.4.99.2),
                     strong similarity to e.g. MUTA_STRCM|Q05064
                     methylmalonyl-coa mutase beta-subunit from Streptomyces
                     cinnamonensis (616 aa), FASTA scores: opt: 1512, E(): 0,
                     (45.9% identity in 628 aa overlap). Contains PS00213
                     Lipocalin signature, PS00544 Methylmalonyl-CoA mutase
                     signature. BELONGS TO THE METHYLMALONYL-COA MUTASE FAMILY.
                     Protein product from Mb1529 detected using shotgun mass
                     spectrometry. Mb1529 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P65486"
                     /db_xref="InterPro:IPR004608"
                     /db_xref="InterPro:IPR006099"
                     /db_xref="InterPro:IPR016176"
                     /db_xref="InterPro:IPR036724"
                     /db_xref="UniProtKB/Swiss-Prot:P65486"
BEGIN
        1 MSIDVPERAD LEQVRGRWRN AVAGVLSKSN RTDSAQLGDH PERLLDTQTA DGFAIRALYT
       61 AFDELPEPPL PGQWPFVRGG DPLRDVHSGW KVAEAFPANG ATADTNAAVL AALGEGVSAL
      121 LIRVGESGVA PDRLTALLSG VYLNLAPVIL DAGADYRPAC DVMLALVAQL DPGQRDTLSI
      181 DLGADPLTAS LRDRPAPPIE EVVAVASRAA GERGLRAITV DGPAFHNLGA TAATELAATV
      241 AAAVAYLRVL TESGLVVSDA LRQISFRLAA DDDQFMTLAK MRALRQLWAR VAEVVGDPGG
      301 GAAVVHAETS LPMMTQRDPW VNMLRCTLAA FGAGVGGADT VLVHPFDVAI PGGFPGTAAG
      361 FARRIARNTQ LLLLEESHVG RVLDPAGGSW FVEELTDRLA RRAWQRFQAI EARGGFVEAH
      421 DFLAGQIAEC AARRADDIAH RRLAITGVNE YPNLGEPALP PGDPTSPVRR YAAGFEALRD
      481 RSDHHLARTG ARPRVLLLPL GPLAEHNIRT TFATNLLASG GIEAIDPGTV DAGTVGNAVA
      541 DAGSPSVAVI CGTDARYRDE VADIVQAARA AGVSRVYLAG PEKALGDAAH RPDEFLTAKI
      601 NVVQALSNLL TRLGA
//