LOCUS       SIU00117.1               241 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            invasion protein protein.
ACCESSION   LT708304-1530
PROTEIN_ID  SIU00117.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1514"
                     /note="Mb1514, -, len: 241 aa. Equivalent to Rv1478, len:
                     241 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 241 aa overlap). Hypothetical Invasion
                     protein. Possibly exported protein, nearly identical to
                     AF0060|AF006054_2 hypothetical invasion protein INV2 of M.
                     tuberculosis (240 aa), FASTA scores: opt: 1509, E(): 0,
                     (95.0% identity in 241 aa overlap); very similar to
                     AF0021|AF002133_5 hypothetical invasion protein INV2 from
                     Mycobacterium avium (244 aa), FASTA scores: opt: 1269,
                     E():0, (78.0% identity in 246 aa overlap). Also similar to
                     Mycobacterium tuberculosis protein MTCY336.37 and weakly
                     similar to C-terminal segment of p60 proteins of Listeria
                     spp.e.g. Q01836|P60_LISIN PROTEIN P60 PRECURSOR (481 aa),
                     FASTA scores: opt: 241, E():4e-07, (37.7% identity in 122
                     aa overlap). Highly similar to C-terminal domain of
                     preceeding ORF Rv1477|MTV007.24 (472 aa), FASTA scores:
                     opt: 864, E(): 0, (60.1% identity in 213 aa overlap).
                     Mb1514 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="InterPro:IPR000064"
                     /db_xref="InterPro:IPR038765"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYH7"
BEGIN
        1 MRHTRFHPIK LAWITAVVAG LMVGVATPAD AEPGQWDPTL PALVSAGAPG DPLAVANASL
       61 QATAQATQTT LDLGRQFLGG LGINLGGPAA SAPSAATTGA SRIPRANARQ AVEYVIRRAG
      121 SQMGVPYSWG GGSLQGPSKG VDSGANTVGF DCSGLVRYAF AGVGVLIPRF SGDQYNAGRH
      181 VPPAEAKRGD LIFYGPGGGQ HVTLYLGNGQ MLEASGSAGK VTVSPVRKAG MTPFVTRIIE
      241 Y
//